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VPS26B - VPS26 retromer complex component B Gene

Also Known as Pep8b

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 112936

About VPS26B

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:134,224,671-134,247,788 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 21.5), skin (RPKM 15.9) and 25 other tissues.

Summary

Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in early endosome and late endosome. Predicted to be part of retromer complex. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Apr 2022]

VPS26B Products (1)

mRNA	Protein	Name
NM_052875.5	NP_443107.1	vacuolar protein sorting-associated protein 26B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24980502	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS26B Protein Structure

Vps26

0
100
200
300
336 a.a.

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 26B	vesicle protein sorting 26B

VPS26B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS26B	Q4G0F5	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	28514442
Intra	VPS26B	Q4G0F5	VPS35	Homo sapiens	Q96QK1	Validated Y2H	32296183
Intra	VPS26B	Q4G0F5	VPS35	Homo sapiens	Q96QK1	Y2H Array	32296183
Intra	VPS26B	Q4G0F5	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	26496610
Intra	VPS26B	Q4G0F5	VPS35	Homo sapiens	Q96QK1	Anti Tag CoIP	33961781
Intra	VPS26B	Q4G0F5	VPS35	Homo sapiens	Q96QK1	Y2H Prey Pooling	32296183
Intra	VPS26B	Q4G0F5	NPLOC4	Homo sapiens	Q8TAT6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 56	Mental Retardation, Autosomal Dominant 56 MRD56 Autosomal Dominant Mental Retardation 56 Autosomal Dominant Intellectual Developmental Disorder 56 Autosomal Dominant Intellectual Developmental Disorder-56
Developmental And Epileptic Encephalopathy 48	DEE48 Epileptic Encephalopathy, Early Infantile, 48 Eiee48 Developmental And Epileptic Encephalopathy, 48 Early Infantile Epileptic Encephalopathy 48
Spastic Paraplegia 39, Autosomal Recessive	SPG39 Ntemnd Hereditary Spastic Paraplegia 39 Nte-Related Motor Neuron Disorder Autosomal Recessive Spastic Paraplegia Type 39 Spastic Paraplegia Due To Neuropathy Target Esterase Mutation Spastic Paraplegia Due To Nte Mutation Spastic Paraplegia 39 Autosomal Recessive Spastic Paraplegia 39 Nte Related Motor Neuron Disorder Paraplegia, Spastic, Type 39
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15680	VPS26B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VPS26B	MGD	MGI:1917656
Bos taurus	VPS26B	VGNC	VGNC:36815
Canis familiaris	VPS26B	VGNC	VGNC:48281
Rattus norvegicus	VPS26B	RGD	RGD:1597170
Macaca mulatta	VPS26B	VGNC	VGNC:101426
Felis catus	VPS26B	VGNC	VGNC:66961
Others	VPS26B	NCBI