NOS1AP - nitric oxide synthase 1 adaptor protein Gene

Also Known as CAPON; NPHS22; 6330408P19Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9722

About NOS1AP

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:162,069,691-162,370,475 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues, 11 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 5.4), adrenal (RPKM 1.1) and 11 other tissues.

Summary

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

NOS1AP Products (3)

mRNA	Protein	Name
NM_001126060.2	NP_001119532.2	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 2
NM_001164757.2	NP_001158229.1	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 3
NM_014697.3	NP_055512.1	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	26869880	GOA
involved in postsynaptic actin cytoskeleton organization	IEP IEP: Inferred from expression pattern	26869880	GOA
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	26869880	GOA
involved in regulation of heart rate by chemical signal	IMP IMP: Inferred from mutant phenotype	19247217	GOA
involved in regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	19247217	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26869880	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26869880	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOS1AP Protein Structure

PID

0
100
200
300
400
506 a.a.

Protein Preferred Names	Protein Names
carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)

NOS1AP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOS1AP	O75052	FAM133A	Homo sapiens	Q8N9E0	Y2H Array	25416956
Intra	NOS1AP	O75052	FAM133A	Homo sapiens	Q8N9E0	Y2H Prey Pooling	25416956
Intra	NOS1AP	O75052	FAM133A	Homo sapiens	Q8N9E0	Validated Y2H	25416956
Intra	NOS1AP	O75052	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	25416956
Intra	NOS1AP	O75052	NKAP	Homo sapiens	Q8N5F7	Y2H Array	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nephrotic Syndrome, Type 22	NPHS22 Nephrotic Syndrome Type 22 Nephrotic Syndrome 22
Paranoid Personality Disorder
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Acute Ethmoiditis	Acute Ethmoidal Sinusitis Acute Ethmoid Sinusitis Ethmoidal Sinus - Acute
Short Qt Syndrome	Sqts Familial Short Qt Syndrome
Long Qt Syndrome 13	LQT13 Qt Syndrome, Long, Type 13
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Long Qt Syndrome 2	LQT2 Long Qt Syndrome, Acquired, Reduced Susceptibility To Long Qt Syndrome 1/2 Long Qt Syndrome 2/3 Long Qt Syndrome 2/5 Long Qt Syndrome 2, Acquired, Susceptibility To Long Qt Syndrome, Acquired, Reduced Long Qt Syndrome Type 2 Long Qt Syndrome 2/9 Lqt1/2 Lqt2/3 Lqt2/5 Lqt2/9 Susceptibility To Acquired Long Qt Syndrome 2 Long Qt Syndrome-2 Qt Syndrome, Long, Type 2 Long Qt Syndrome 1-2 Long Qt Syndrome 2-3 Long Qt Syndrome 2-5 Long Qt Syndrome 9
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Long Qt Syndrome 3	LQT3 Long Qt Syndrome Type 3 Long Qt Syndrome-3 Qt Syndrome, Long, Type 3
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Catecholaminergic Polymorphic Ventricular Tachycardia	Cpvt Catecholamine-Induced Polymorphic Ventricular Tachycardia Familial Polymorphic Ventricular Tachycardia Malignant Paroxysmal Ventricular Tachycardia Multifocal Ventricular Premature Beats Stress-Induced Polymorphic Ventricular Tachycardia Bidirectional Tachycardia Induced By Catecholamine Double Tachycardia Induced By Catecholamines Polymorphic Catecholergic Ventricular Tachycardia Syncopal Paroxysmal Tachycardia Bidirectional Tachycardia Induced By Catecholamines Fpvt Bidirectional Ventricular Tachycardia Induced By Catecholamine Polymorphic Ventricular Tachycardia Induced By Catecholamines Ventricular Tachycardia, Catecholaminergic Polymorphic Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 Familial Ventricular Tachycardia Multifocal Pvcs Multifocal Premature Ventricular Beats
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124996	(Rac)-ZLc-002	Inhibitor	98.96%	Unkown
HY-RS09436	NOS1AP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19265	Nos1ap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25754	Nos1ap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NOS1AP	VGNC	VGNC:55636
Rattus norvegicus	NOS1AP	RGD	RGD:620106
Mus musculus	NOS1AP	MGD	MGI:1917979
Others	NOS1AP	NCBI