2. Apoptosis
  3. Apoptosis
  4. GL-331

GL-331 is a potent anti-cancer agent. GL-331 has demonstrated more efficacious anti-cancer activity in both the in vitro and in vivo lymphoma systems.

For research use only. We do not sell to patients.

GL-331

GL-331 Chemical Structure

CAS No. : 127882-73-9

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GL-331 Related Antibodies

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Description

GL-331 is a potent anti-cancer agent. GL-331 has demonstrated more efficacious anti-cancer activity in both the in vitro and in vivo lymphoma systems[1].

Cellular Effect
Cell Line Type Value Description References
1A9 ED50
< 1.6 μM
Compound: 6
Effective dose of compound against replication of 1A9 cell line was evaluated
Effective dose of compound against replication of 1A9 cell line was evaluated
[PMID: 15006408]
A549 ED50
< 0.1 μM
Compound: 6
Effective dose of compound against replication of A549 cell line was evaluated
Effective dose of compound against replication of A549 cell line was evaluated
[PMID: 15006408]
A549 IC50
0.113 μg/mL
Compound: GL-331
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 22658864]
A549 IC50
15.8 nM
Compound: Ref 34, Cpd 4
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 32992133]
CAKI-1 ED50
1.5 mM
Compound: GL331
The compound was tested for tumor cell growth inhibitory activity against human renal cancer(CAKI-1) cell line
The compound was tested for tumor cell growth inhibitory activity against human renal cancer(CAKI-1) cell line
[PMID: 10395485]
DU-145 IC50
0.8 μg/mL
Compound: GL-331
Cytotoxicity against human DU145 cells by SRB assay
Cytotoxicity against human DU145 cells by SRB assay
[PMID: 22658864]
H9 EC50
< 0.00128 μM
Compound: 15
Evaluation for anti-HIV activity using T cell line (H9).
Evaluation for anti-HIV activity using T cell line (H9).
10.1016/S0960-894X(97)10108-1
H9 IC50
0.07 μM
Compound: 15
Cytotoxicity against H9 cell line
Cytotoxicity against H9 cell line
10.1016/S0960-894X(97)10108-1
HCT-8 ED50
1.6 μM
Compound: 6
Effective dose of compound against replication of HCT-8 cell line was evaluated
Effective dose of compound against replication of HCT-8 cell line was evaluated
[PMID: 15006408]
HCT-8 ED50
8.5 mM
Compound: GL331
The compound was tested for tumor cell growth inhibitory activity against human ileocecal carcinoma (HCT-8) cell line
The compound was tested for tumor cell growth inhibitory activity against human ileocecal carcinoma (HCT-8) cell line
[PMID: 10395485]
HOS ED50
< 1.6 μM
Compound: 6
Effective dose of compound against replication of HOS cell line was evaluated
Effective dose of compound against replication of HOS cell line was evaluated
[PMID: 15006408]
KB ED50
0.2 μg/mL
Compound: 6
Dose required to cause reduction in human nasopharyngeal KB cancer cells after 3 days incubation
Dose required to cause reduction in human nasopharyngeal KB cancer cells after 3 days incubation
[PMID: 15456257]
KB ED50
0.2 μg/mL
Compound: 63, NSC-628679
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
[PMID: 20187635]
KB ED50
0.49 mM
Compound: GL331
The compound was tested for tumor cell growth inhibitory activity against human nasopharynx carcinoma(KB) cell line.
The compound was tested for tumor cell growth inhibitory activity against human nasopharynx carcinoma(KB) cell line.
[PMID: 10395485]
KB ED50
1.5 μM
Compound: 4
Effective dose required for inhibition of KB-7d cell replication after 3 days of continuous treatment
Effective dose required for inhibition of KB-7d cell replication after 3 days of continuous treatment
[PMID: 15125972]
KB ED50
1.5 μM
Compound: 6
Effective dose of compound against replication of KB/7d cell line was evaluated
Effective dose of compound against replication of KB/7d cell line was evaluated
[PMID: 15006408]
KB ED50
2 μg/mL
Compound: 6
Dose required for reduction in human nasopharyngeal KB-7d cancer cells after 3 days incubation
Dose required for reduction in human nasopharyngeal KB-7d cancer cells after 3 days incubation
[PMID: 15456257]
KB ED50
3.5 μM
Compound: 6
Effective dose of compound against replication of KB cell line was evaluated
Effective dose of compound against replication of KB cell line was evaluated
[PMID: 15006408]
KB ED50
4.1 μM
Compound: 6
Effective dose of compound against replication of KB-Vin cell line was evaluated
Effective dose of compound against replication of KB-Vin cell line was evaluated
[PMID: 15006408]
KB IC50
0.032 μM
Compound: 1
Growth inhibitory activity (antiproliferative) against KB cell lines
Growth inhibitory activity (antiproliferative) against KB cell lines
[PMID: 8691469]
KB IC50
0.49 μM
Compound: 15
Concentration required for 50% reduction in KB cell number after 3-day incubation
Concentration required for 50% reduction in KB cell number after 3-day incubation
[PMID: 1312600]
KB IC50
0.49 μM
Compound: 32
Concentration required for 50% reduction in KB cell number after 3-day incubation
Concentration required for 50% reduction in KB cell number after 3-day incubation
[PMID: 1312601]
KB IC50
0.49 μM
Compound: 63, NSC-628679
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
[PMID: 20187635]
KB IC50
0.55 μM
Compound: 1
Growth inhibitory activity (antiproliferative) against KB/7d cell lines
Growth inhibitory activity (antiproliferative) against KB/7d cell lines
[PMID: 8691469]
KB IC50
0.819 μg/mL
Compound: GL-331
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
[PMID: 22658864]
KB IC50
3 μM
Compound: 63, NSC-628679
Cytotoxicity against human vincristine-resistant KB cells after 72 hrs by MTT assay
Cytotoxicity against human vincristine-resistant KB cells after 72 hrs by MTT assay
[PMID: 20187635]
MCF7 ED50
24.5 μM
Compound: 6
Effective dose of compound against replication of MCF-7 cell line was evaluated
Effective dose of compound against replication of MCF-7 cell line was evaluated
[PMID: 15006408]
MCF7 ED50
28.5 mM
Compound: GL331
The compound was tested for tumor cell growth inhibitory activity against human breast cancer (MCF-7) cell line.
The compound was tested for tumor cell growth inhibitory activity against human breast cancer (MCF-7) cell line.
[PMID: 10395485]
MCF7 IC50
15.8 nM
Compound: Ref 34, Cpd 4
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 32992133]
PC-3 ED50
8.9 μM
Compound: 6
Effective dose of compound against replication of PC-3 cell line was evaluated
Effective dose of compound against replication of PC-3 cell line was evaluated
[PMID: 15006408]
PC-3 IC50
15.8 nM
Compound: Ref 34, Cpd 4
Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay
[PMID: 32992133]
SK-MEL-2 ED50
16.5 mM
Compound: GL331
The compound was tested for tumor cell growth inhibitory activity against human melanoma (SKMEL-2) cell line.
The compound was tested for tumor cell growth inhibitory activity against human melanoma (SKMEL-2) cell line.
[PMID: 10395485]
SK-MEL-2 ED50
3 μM
Compound: 6
Effective dose of compound against replication of SK-MEL-2 cell line was evaluated
Effective dose of compound against replication of SK-MEL-2 cell line was evaluated
[PMID: 15006408]
U-373MG ATCC IC50
1 nM
Compound: 42; GL331
Inhibition of HIF-1alpha in human U373 cells
Inhibition of HIF-1alpha in human U373 cells
[PMID: 30682255]
U-87MG ATCC ED50
5.5 μM
Compound: 6
Effective dose of compound against replication of U87MG cell line was evaluated
Effective dose of compound against replication of U87MG cell line was evaluated
[PMID: 15006408]
In Vitro

GL-331 shows more efficacy than VP-16 (HY-13629) in killing cancer cells. GL-331 possesses more cell-killing activity even in MDR-1-overexpressing cell lines such as HCC36 and SW620. Its higher cytotoxicity can be attributed by the elevated ability to induce apoptotic cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GL-331 Related Antibodies
Molecular Weight

520.49

Formula

C27H24N2O9
CAS No.
SMILES

O=C1OC[C@]2([H])[C@H](NC3=CC=C([N+]([O-])=O)C=C3)C4=C(C=C5OCOC5=C4)[C@@H](C6=CC(OC)=C(O)C(OC)=C6)[C@]21[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GL-331 Related Classifications

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  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GL-331127882-73-9GL331GL 331ApoptosisHCC36SW620anti-cancerInhibitorinhibitorinhibit

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