2. Peptides
  3. GRGDSPC TFA

GRGDSPC TFA, a 7-amino acid peptide, is a thiolated cell adhesion peptide.

For research use only. We do not sell to patients.

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GRGDSPC TFA Chemical Structure

GRGDSPC TFA Chemical Structure

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1 mg USD 65 In-stock
5 mg USD 190 In-stock
10 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of GRGDSPC TFA:

GRGDSPC TFA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

GRGDSPC TFA, a 7-amino acid peptide, is a thiolated cell adhesion peptide[1].

In Vitro

GRGDSPC is conjugated to acrylated dextran via thiol-acrylate reaction to regulate the interactions of human mesenchymal stem cells (hMSCs) with the photocrosslinkable hydrogels. To determine the conjugation kinetics and efficiency of GRGDSPC peptide to DEX-MAES16, various GRGDSPC concentrations (i.e., 5, 10 and 20 mg/1 g DEX-MAES16) are conjugated to the acrylated Dextran (DEX) macromer over time (0.25, 0.5, 1 and 3h) in PBS at pH 7.8 and the free thiol groups of unreacted peptides are quantified using Ellman’s assay. In addition, the reaction kinetics of the thiol-peptide to acrylated (DEX-MAES16) and methacrylated (DEX-HEMA16) macromers are compared. As early as 15 min conjugation, with 5, 10 and 20 mg of GRGDSPC peptide/1 g modified DEX, the peptide conjugation efficiencies with DEX-MAES are 105.40, 94.10 and 87.45%, respectively, while for the reaction with the DEX-HEMA they are 0.73, 15.78 and 18.42%, respectively. After 1h, the GRGDSPC conjugation with DEX-MAES is completed with the peptide concentration of 10 mg, but only 35.66% of the thiol groups of the peptide react with DEX-HEMA. The reaction kinetics are also monitored at 3 h of conjugation, and all of the 20 mg GRGDSPC peptide reacts with acrylated DEX compared to only 32.53% for the methacrylated DEX at this time point[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GRGDSPC TFA Related Antibodies
Molecular Weight

804.75

Formula

C27H43F3N10O13S
Appearance

Solid

Color

White to off-white

Sequence

Gly-Arg-Gly-Asp-Ser-Pro-Cys
Sequence Shortening

GRGDSPC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (124.26 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2426 mL 6.2131 mL 12.4262 mL
5 mM 0.2485 mL 1.2426 mL 2.4852 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.2426 mL 6.2131 mL 12.4262 mL 31.0655 mL
5 mM 0.2485 mL 1.2426 mL 2.4852 mL 6.2131 mL
10 mM 0.1243 mL 0.6213 mL 1.2426 mL 3.1066 mL
15 mM 0.0828 mL 0.4142 mL 0.8284 mL 2.0710 mL
20 mM 0.0621 mL 0.3107 mL 0.6213 mL 1.5533 mL
25 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2426 mL
30 mM 0.0414 mL 0.2071 mL 0.4142 mL 1.0355 mL
40 mM 0.0311 mL 0.1553 mL 0.3107 mL 0.7766 mL
50 mM 0.0249 mL 0.1243 mL 0.2485 mL 0.6213 mL
60 mM 0.0207 mL 0.1036 mL 0.2071 mL 0.5178 mL
80 mM 0.0155 mL 0.0777 mL 0.1553 mL 0.3883 mL
100 mM 0.0124 mL 0.0621 mL 0.1243 mL 0.3107 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRGDSPCOthersInhibitorinhibitorinhibit

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