huAA98 

huAA98 is a humanized monoclonal antibody and also a CD146 inhibitor. huAA98 binds to human CD146, regulates its activity and inhibits cancer-related angiogenesis, as well as tube formation, motility, proliferation and migration of endothelial cells. huAA98 inhibits angiogenesis in the chick chorioallantoic membrane assay and reduces microvessel density in human tumor xenograft models. huAA98 shows immunoreactivity only to neovascular vessels within tumors and inhibits the growth of tumor xenograft models. huAA98 can be used in studies related to cancer-related angiogenesis, liver cancer, leiomyosarcoma and pancreatic cancer^[1][2].

Human

huAA98 is the humanized version of the anti-CD146 mAb AA98, which inhibits angiogenesis and suppresses the growth of various tumors^[1].
huAA98 maintains specific binding activity to CD146 at both the molecular and cellular level, binding strongly to CD146-positive cell lines including HUVECs and showing no binding to CD146-negative cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4162  [NCBI]

P43121

MUC18/MCAM/CD146

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang F, et al. A novel 'pipeline' system for downstream preparation of therapeutic monoclonal antibodies. Biotechnol Lett. 2013;35(9):1411-1418.

  [2]. Yan X, et al. A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth. Blood. 2003;102(1):184-191.