Hydroxy-PEG2-acid

Art. -Nr.: HY-124380 Reinheit: 97.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Hydroxy-PEG2-acid Chemische Struktur

CAS. Nr. : 1334286-77-9

Größe	Verfügbarkeit	Menge
100 mg	Auf Lager	Estimated Time of Arrival: December 31
250 mg	Auf Lager	Estimated Time of Arrival: December 31
500 mg	Auf Lager	Estimated Time of Arrival: December 31
1 g	Auf Lager	Estimated Time of Arrival: December 31
5 g	Auf Lager	Estimated Time of Arrival: December 31
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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Beschreibung

Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

178.18

Formel

C₇H₁₄O₅

CAS. Nr.

1334286-77-9

Appearance

Liquid (Density: 1.196 g/cm³)

Color

Colorless to light yellow

SMILES

OC(CCOCCOCCO)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : ≥ 100 mg/mL (561.23 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6123 mL	28.0615 mL	56.1230 mL
5 mM	1.1225 mL	5.6123 mL	11.2246 mL
10 mM	0.5612 mL	2.8062 mL	5.6123 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

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Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 97.0%

Select Batch:

Data Sheet (266 KB) SDS (615 KB)

COA (241 KB) HNMR (131 KB)

Handling Instructions (2659 KB)

Verweise

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	5.6123 mL	28.0615 mL	56.1230 mL	140.3076 mL
	5 mM	1.1225 mL	5.6123 mL	11.2246 mL	28.0615 mL
	10 mM	0.5612 mL	2.8062 mL	5.6123 mL	14.0308 mL
	15 mM	0.3742 mL	1.8708 mL	3.7415 mL	9.3538 mL
	20 mM	0.2806 mL	1.4031 mL	2.8062 mL	7.0154 mL
	25 mM	0.2245 mL	1.1225 mL	2.2449 mL	5.6123 mL
	30 mM	0.1871 mL	0.9354 mL	1.8708 mL	4.6769 mL
	40 mM	0.1403 mL	0.7015 mL	1.4031 mL	3.5077 mL
	50 mM	0.1122 mL	0.5612 mL	1.1225 mL	2.8062 mL
	60 mM	0.0935 mL	0.4677 mL	0.9354 mL	2.3385 mL
	80 mM	0.0702 mL	0.3508 mL	0.7015 mL	1.7538 mL
	100 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.4031 mL