Trh - thyrotropin releasing hormone Gene

Also Known as THR; Trf; TRH01; Pro-TRH

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25569

Summary

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The rat proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as Prolactin, and may be involved in cardiac function in heart failure. Disruption of this gene is associated with hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, May 2013]

Trh Products (1)

mRNA	Protein	Name
NM_013046.3	NP_037178.1	thyrotropin releasing hormone preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables thyrotropin-releasing hormone activity	IDA IDA: Inferred from direct assay	12369739	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in eating behavior	IDA IDA: Inferred from direct assay	16959836	RGD
involved in histamine metabolic process	IDA IDA: Inferred from direct assay	17760865	RGD
involved in negative regulation of feeding behavior	IDA IDA: Inferred from direct assay	17760865	RGD
involved in negative regulation of glutamate secretion	IDA IDA: Inferred from direct assay	16055093	RGD
involved in positive regulation of gamma-aminobutyric acid secretion	IDA IDA: Inferred from direct assay	16990402	RGD
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	16118471	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	16293347	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	15680480	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	15680480	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15726019	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16075386	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in secretory granule	IDA IDA: Inferred from direct assay	3930986	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
thyrotropin releasing hormone	TSH-releasing factor pro-thyrotropin-releasing hormone prothyroliberin protirelin thyrotropin-releasing factor

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0596	Taltirelin		99.91%	Unkown
HY-P0002	Protirelin	Activator	99.98%	Unkown
HY-P0002A	Protirelin acetate	Activator	99.87%	Yes
HY-B0596A	Taltirelin acetate		99.75%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106744	Azetirelin		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y0973	BOP hexafluorophosphate		≥99.0%	Unkown
HY-W009673	Boc-Pyr-OH		99.69%	Unkown
HY-P3960	(Glu2)-TRH	Inhibitor	99.96%	Unkown
HY-P1213	JKC363	Antagonist	99.06%	Unkown
HY-P10485	Glp-Asn-Pro-AMC		99.26%	Unkown
HY-107380A	PGlu-3-methyl-His-Pro-NH2 TFA		99.69%	Unkown
HY-15113A	Y-29794 tosylate	Inhibitor	99.86%	Unkown
HY-117178	TA 0910 acid-type	Control	99.85%	Unkown
HY-118117	Rovatirelin		/	Unkown
HY-15113	Y-29794	Inhibitor	/	Unkown
HY-19154	Montirelin		/	Unkown
HY-B0596S	Taltirelin-13C,d3		/	Unkown
HY-P1213A	JKC363 TFA	Antagonist	/	Unkown
HY-P3962	[Phe2]-TRH		/	Unkown
HY-P3964	TRH Precursor Peptide		/	Unkown
HY-P3969	Prepro-TRH-(160-169)	Agonist	/	Unkown
HY-P4367	TRH-AMC		/	Unkown
HY-P4584	TRH-βNA		/	Unkown
HY-RS15011	TRH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W345393	Trh-gly	Agonist	/	Unkown
HY-122353	Orotirelin		/	Unkown
HY-136800	Posatirelin	Inhibitor	/	Unkown
HY-RS16699	Trh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23133	Trh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trh	NCBI	NCBI:7200