Indoluidin D
Indoluidin D is a selective dihydroorotate dehydrogenase (DHODH) inhibitor with a human DHODH IC50 of 210 nM. Indoluidin D selectively inhibits human DHODH activity, with induced effects rescuable by orotic acid. Indoluidin D promotes myeloid differentiation and inhibits cancer cell proliferation. Indoluidin D can be used for the research of acute promyelocytic leukemia.
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- CAS. Nr.: 2763081-61-2
- Formel: C28H28N4O2
- Molecular Weight:452.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
128 nM
Compound: 49
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Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
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[PMID: 35151222] |
Indoluidin D (0.01-1000 nM; 96 h) induces myeloid differentiation in human promyelocytic leukemia HL-60 cells with an EC50 of 10 nM, and this effect is specifically reversed by orotic acid[1].
Indoluidin D (72 h) inhibits growth of multiple human cancer cell lines, with the highest potency against acute T cell leukemia Jurkat cells (IC50 = 0.68 nM) and the lowest activity against normal pancreatic 1B2C6/1C3D3 and osteosarcoma Saos-2/MG-63 cells[1].
Indoluidin D (1-1000 nM; 30 min preincubation) inhibits recombinant human DHODH/ΔTM enzyme activity with an IC50 of 210 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human promyelocytic leukemia HL-60 cells
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Concentration:0, 10, 20, 30, 40 nM
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Incubation Time:96 h
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Result:Potently induced myeloid differentiation of HL-60 cells, with an EC50 of 10 nM.
Induced expression of CD11b, a myeloid differentiation marker, in HL-60 cells.
Induced differentiation was rescued by addition of 1 mM orotic acid but not 1 mM dihydroorotic acid.
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Cell Line:human promyelocytic leukemia HL-60 cells
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Concentration:0.01, 0.1, 1, 10, 100, 1000 nM
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Incubation Time:72 h
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Result:Potently suppressed viability and proliferation of HL-60 cells, with an IC50 of 4.4 nM.
Chemical Information
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CAS. Nr. 2763081-61-2
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Molecular Weight 452.55
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Formel C28H28N4O2
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SMILES
O=C([C@H]1CC2=CC=CC=C2CN1)N[C@@H](C(NC3=CC=C(C=C3)C)=O)CC4=CNC5=CC=CC=C45
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Indoluidin D Related Classifications
HY-182550 Related Classifications
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- Indoluidin D
- 2763081-61-2
- Dihydroorotate Dehydrogenase
- HeLa cells
- orotic acid
- dihydroorotate dehydrogenase
- acute promyelocytic leukemia
- human DHODH
- myeloid differentiation
- normal pancreatic 1B2C6/1C3D3 cells
- human promyelocytic leukemia HL-60 cells
- osteosarcoma Saos-2 cells
- acute T cell leukemia Jurkat cells
- Inhibitor
- inhibitor
- inhibit