13(S)-HPODE
Based on 1 publication(s) in Google Scholar
13(S)-HPODE is a linoleic acid metabolite found in several plants and mammals.
For research use only. We do not sell to patients.
- Purity: 95.05%
- CAS No.: 33964-75-9
- Formula: C18H32O4
- Molecular Weight:312.44
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 13(S)-HPODE
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Biological Activity
13(S)-HPODE can be produced by the oxidation of linoleic acid by lipoxygenase-1 in many plants[1]. The dioxygenation catalyzed by a 15-lipoxygenase and a reduction of intermediate 13-HPODE by a glutathione-dependent peroxidase can form 13(S)-HODE[2]. 13(S)-HPODE can stimulate EGF-dependent mitogenesis and up-regulation of EGF-dependent tyrosine phosphorylation by inhibiting the dephosphorylation of the EGFR[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 33964-75-9
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Appearance Liquid
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Molecular Weight 312.44
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Formula C18H32O4
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Color Colorless to light yellow
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SMILES
CCCCC[C@H](OO)/C=C/C=C\CCCCCCCC(O)=O
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
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Data Sheet (264 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Gardner HW, et al. Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. Biochim Biophys Acta. 1989 Feb 20;1001(3):274-81. [Content Brief]
[2]. Reinaud O, et al. Oxidative metabolism of linoleic acid by human leukocytes. Biochem Biophys Res Commun. 1989 Jun 15;161(2):883-91. [Content Brief]
[3]. Glasgow WC, et al. The linoleic acid metabolite, (13S)-hydroperoxyoctadecadienoic acid, augments the epidermal growth factor receptor signaling pathway by attenuation of receptor dephosphorylation. Differential response in Syrian hamster embryo tumor suppressor phenotypes. J Biol Chem. 1997 Aug 1;272(31):19269-76. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
13(S)-HPODE Related Classifications
HY-110406 Related Classifications
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