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Cat. No.: HY-168876

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AZ14240475

AZ14240475 is a potent, selective, and brain-penetrant inhibitor of EGFR Ex20Ins mutants, with the pIC₅₀ of 7.6. AZ14240475 plays an important role in cancer research.

For research use only. We do not sell to patients.

Formula: C₂₃H₁₅ClF₂N₆O₂
Molecular Weight:480.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AZ14240475 Chemical Structure

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AZ14240475 is a potent, selective, and brain-penetrant inhibitor of EGFR Ex20Ins mutants, with the pIC₅₀ of 7.6. AZ14240475 plays an important role in cancer research^[1].

IC₅₀ & Target

EGFR exon 20 insertion

All EGFR Isoforms :

Chemical Information

Molecular Weight 480.85
Formula C₂₃H₁₅ClF₂N₆O₂
SMILES

C=CC(N1CC2=C(C1)N(C3=CC=NC=N3)C(C4=C(F)C=C(F)C(OC5=NC=CC(Cl)=C5)=C4)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. William McCoull, et al. Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations. J Med Chem. 2025 Jan 27. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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MCE Japan Authorized Agent:

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AZ14240475

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AZ14240475 Related Classifications

HY-168876 Related Classifications