Wwp1 - WW domain containing E3 ubiquitin protein ligase 1 Gene

Also Known as AIP5; SDRP1; Tiul1; 8030445B08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107568

Summary

Enables ubiquitin protein Ligase activity. Involved in negative regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in limb and limb mesenchyme. Orthologous to human WWP1 (WW domain containing E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Wwp1 Products (3)

mRNA Protein Name
NM_001276292.1 NP_001263221.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform 2
NM_001355222.1 NP_001342151.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform 3
NM_177327.5 NP_796301.2 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11375995 MGI
enables ubiquitin protein ligase activity EXP
EXP: Inferred from Experiment
16728642 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19561640 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19561640 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11375995 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19047365 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
19561640 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NEDD4-like E3 ubiquitin-protein ligase WWP1

  • HECT-type E3 ubiquitin transferase WWP1

  • WW domain-containing protein 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0170 Indole-3-carbinol 99.16% Phase 3
HY-N0170R Indole-3-carbinol (Standard) 98.31% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110204 Heclin Inhibitor 98.00% Unkown
HY-134417 NSC2805 Inhibitor 99.42% Unkown
HY-168601 WWP1/2-IN-1 Inhibitor / Unkown
HY-RS18507 Wwp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168602 NSC-217913 Inhibitor / Unkown
HY-RS15860 WWP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24989 Wwp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wwp1 NCBI NCBI:11059