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Cat. No.: HY-168602

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NSC-217913

NSC-217913 is an inhibitor of WWP1 with an IC₅₀ value of 158.3 μM.

For research use only. We do not sell to patients.

CAS No.: 79100-27-9
Formula: C₉H₈Cl₂N₄O₂S
Molecular Weight:307.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NSC-217913 Chemical Structure

CAS No.: 79100-27-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

NSC-217913 is an inhibitor of WWP1 with an IC₅₀ value of 158.3 μM^[1].

Chemical Information

CAS No. 79100-27-9
Molecular Weight 307.16
Formula C₉H₈Cl₂N₄O₂S
SMILES

ClC1=C(Cl)N=C(NC(SCC(OCC)=O)=N2)C2=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dudey A P, et al. Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39(1): 2394895. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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