CCR9 - C-C motif chemokine receptor 9 Gene

Also Known as GPR28; CDw199; GPR-9-6; CC-CKR-9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10803

About CCR9

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,886,064-45,903,174 (from NCBI)

This gene has 4 transcripts (splice variants), 265 orthologues and 23 paralogues. Biased expression in small intestine (RPKM 2.0), duodenum (RPKM 1.6) and 6 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta Chemokine Receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, Apoptosis, invasion, migration and drug resistance. This gene maps to the Chemokine Receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

CCR9 Products (5)

mRNA Protein Name
NM_001386447.1 NP_001373376.1 C-C chemokine receptor type 9 isoform A
NM_006641.4 NP_006632.2 C-C chemokine receptor type 9 isoform B
NM_031200.3 NP_112477.1 C-C chemokine receptor type 9 isoform A
NM_001256369.2 NP_001243298.1 C-C chemokine receptor type 9 isoform B
NM_001386448.1 NP_001373377.1 C-C chemokine receptor type 9 isoform A

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
18308860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCR9 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (65 - 317)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 9

  • G protein-coupled receptor 28

  • chemokine (C-C motif) receptor 9

Recombinant CCR9 Proteins

Cat. No. Product Name Accession Purity
HY-P700544 CCR9 Protein, Human (GST) P51686-1 (M1-S48) ≥ 90%, as determined by reducing SDS-PAGE.

CCR9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83374 CCR9 Antibody (YA3119) WB, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Ascending Cholangitis
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Ileitis

  • Crohn'S Ileitis
Cholangitis, Primary Sclerosing

  • Primary Sclerosing Cholangitis

  • PSC

  • Sclerosing Cholangitis

  • Cholangitis, Sclerosing

  • Cholangitis Primary Sclerosing

  • Psc - [Primary Sclerosing Cholangitis]
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Immunodeficiency 49

  • IMD49

  • Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities

  • Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities

  • Immunodeficiency 49, Severe Combined

  • Scid, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities

  • Severe Combined Immunodeficiency, T-Cell Negative, B-Cell Positive, Nk Cell Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities

  • Scid, T-Cell-Negative, B-Cell-Positive, Nk-Cell-Positive, With Intellectual Disability, Spasticity, And Craniofacial Abnormalities
Precursor T-Cell Acute Lymphoblastic Leukemia

  • T-All

  • Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor T-Cell Acute Lymphocytic Leukemia

  • Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Adult T-Cell Lymphoma/Leukemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15724 Vercirnon Antagonist 98.01% Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15724A Vercirnon sodium Antagonist 98.04% Unkown
HY-181288 CCR9 ligand-Linker Conjugate 1 Ligand / Unkown
HY-181287 PROTAC CCR9 Degrader 1 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CCR9 MGD MGI:1341902
Macaca mulatta CCR9 VGNC VGNC:70742
Felis catus CCR9 VGNC VGNC:102024
Bos taurus CCR9 VGNC VGNC:26989
Canis familiaris CCR9 VGNC VGNC:38917
Rattus norvegicus CCR9 RGD RGD:628750
Others CCR9 NCBI