TIMM10 - translocase of inner mitochondrial membrane 10 Gene

Also Known as TIM10; TIM10A; TIMM10A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26519

About TIMM10

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,528,464-57,530,754 (from NCBI)

This gene has 3 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in kidney (RPKM 18.4), liver (RPKM 14.8) and 25 other tissues.

Summary

The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

TIMM10 Products (1)

mRNA Protein Name
NM_012456.3 NP_036588.1 mitochondrial import inner membrane translocase subunit Tim10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables membrane insertase activity IDA
IDA: Inferred from direct assay
16387659 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14726512 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
16387659 GOA
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
16387659 GOA
Biological Process GO Annotation Evidence References Source
involved in protein insertion into mitochondrial inner membrane IDA
IDA: Inferred from direct assay
16387659 GOA
Cellular Component GO Annotation Evidence References Source
part of TIM22 mitochondrial import inner membrane insertion complex IPI
IPI: Inferred from physical interaction
32901109 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
14726512 GOA
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
14726512 GOA
part of mitochondrial intermembrane space protein transporter complex IDA
IDA: Inferred from direct assay
14726512 GOA
part of mitochondrial intermembrane space protein transporter complex IPI
IPI: Inferred from physical interaction
14726512 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIMM10 Protein Structure

zf-Tim10_DDP

zf-Tim10_DDP: Tim10/DDP family zinc finger (7 - 71)

  • 0
  • 90 a.a.
Protein Preferred Names Protein Names

mitochondrial import inner membrane translocase subunit Tim10

  • translocase of inner mitochondrial membrane 10 homolog

TIMM10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TIMM10 P62072 TIMM9 Homo sapiens Q9Y5J7
Anti Bait CoIP
14726512
Intra
TIMM10 P62072 TIMM9 Homo sapiens Q9Y5J7
GMS
14726512
Intra
TIMM10 P62072 TIMM9 Homo sapiens Q9Y5J7
Anti Tag CoIP
33961781
Intra
TIMM10 P62072 TBC1D21 Homo sapiens Q8IYX1
Validated Y2H
32296183
Intra
TIMM10 P62072 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
TIMM10 P62072 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
TIMM10 P62072 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

TIMM10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810078 Tim10/TIMM10 Antibody (YA9422) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Mohr-Tranebjaerg Syndrome

  • Deafness-Dystonia-Optic Neuronopathy Syndrome

  • Jensen Syndrome

  • Deafness Dystonia Syndrome

  • MTS

  • Dds

  • Deafness-Dystonia-Optic Atrophy Syndrome

  • Deafness Syndrome, Progressive, With Blindness, Dystonia, Fractures, And Mental Deficiency

  • Opticoacoustic Nerve Atrophy With Dementia

  • Dystonia-Deafness Syndrome

  • Ddp

  • Ddon Syndrome

  • Mohr-Tranebjærg Syndrome

  • Deafness Dystonia Optic Atrophy Syndrome

  • Deafness Dystonia Optic Neuronopathy Syndrome

  • Dystonia Deafness Syndrome

  • Ddon

  • Deafness - Dystonia - Optic Neuronopathy Syndrome

  • Deafness-Dystonia-Optic Neuronopathy Syndrome

  • Hearing Loss-Dystonia-Optic Neuronopathy Syndrome

  • Dfn-1

  • X-Linked Progressive Deafness Type 1
Sennetsu Fever

  • Sennetsu Ehrlichiosis

  • Human Ehrlichial Infection, Sennetsu Type
Sengers Syndrome

  • Mitochondrial Dna Depletion Syndrome 10

  • Cardiomyopathy And Cataract

  • Cataract And Cardiomyopathy

  • MTDPS10

  • Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome

  • Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10

  • Senger Syndrome
Visual Cortex Disease

  • Visual Cortex Dysfunction

  • Visual Cortex Disorder

  • Visual Cortical Disorder

  • Disease Of Visual Cortex
Visual Pathway Disease

  • Disorder Of Visual Pathways
Lymph Node Tuberculosis

  • King'S Evil

  • Scrofula

  • Tuberculous Adenitis

  • Tuberculous Lymphadenopathy

  • Tuberculosis, Lymph Node
Spinocerebellar Ataxia 28

  • Spinocerebellar Ataxia Type 28

  • SCA28

  • Ataxia, Spinocerebellar, Type 28
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Cortical Blindness

  • Blindness, Cortical
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14527 TIMM10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22862 Timm9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TIMM10 VGNC VGNC:81928
Mus musculus TIMM10 MGD MGI:1353429
Canis familiaris TIMM10 VGNC VGNC:49618
Bos taurus TIMM10 VGNC VGNC:97317
Macaca mulatta TIMM10 VGNC VGNC:107651
Rattus norvegicus TIMM10 RGD RGD:621741
Others TIMM10 NCBI