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TIMM9 - translocase of inner mitochondrial membrane 9 Gene

Also Known as TIM9; TIM9A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26520

About TIMM9

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:58,408,494-58,427,531 (from NCBI)

This gene has 10 transcripts (splice variants) and 167 orthologues. Ubiquitous expression in thyroid (RPKM 11.9), ovary (RPKM 11.7) and 25 other tissues.

Summary

TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

TIMM9 Products (8)

mRNA	Protein	Name
NM_001304485.2	NP_001291414.1	mitochondrial import inner membrane translocase subunit Tim9 isoform a
NM_001304486.1	NP_001291415.1	mitochondrial import inner membrane translocase subunit Tim9 isoform a
NM_001304487.2	NP_001291416.1	mitochondrial import inner membrane translocase subunit Tim9 isoform a
NM_001304488.1	NP_001291417.1	mitochondrial import inner membrane translocase subunit Tim9 isoform b
NM_001304489.1	NP_001291418.1	mitochondrial import inner membrane translocase subunit Tim9 isoform c
NM_001304490.1	NP_001291419.1	mitochondrial import inner membrane translocase subunit Tim9 isoform d
NM_001304491.1	NP_001291420.1	mitochondrial import inner membrane translocase subunit Tim9 isoform d
NM_012460.4	NP_036592.1	mitochondrial import inner membrane translocase subunit Tim9 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables membrane insertase activity	IDA IDA: Inferred from direct assay	16387659	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14726512	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	16387659	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	16387659	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein insertion into mitochondrial inner membrane	IDA IDA: Inferred from direct assay	16387659	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of TIM22 mitochondrial import inner membrane insertion complex	IPI IPI: Inferred from physical interaction	32901109	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	14726512	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	14726512	GOA
part of mitochondrial intermembrane space protein transporter complex	IDA IDA: Inferred from direct assay	14726512	GOA
part of mitochondrial intermembrane space protein transporter complex	IPI IPI: Inferred from physical interaction	14726512	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIMM9 Protein Structure

zf-Tim10_DDP

0
89 a.a.

Protein Preferred Names	Protein Names
mitochondrial import inner membrane translocase subunit Tim9	translocase of inner mitochondrial membrane 9 homolog

TIMM9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TIMM9	Q9Y5J7	TIMM10	Homo sapiens	P62072	Anti Bait CoIP	14726512
Intra	TIMM9	Q9Y5J7	TIMM10	Homo sapiens	P62072	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mohr-Tranebjaerg Syndrome	Deafness-Dystonia-Optic Neuronopathy Syndrome Jensen Syndrome Deafness Dystonia Syndrome MTS Dds Deafness-Dystonia-Optic Atrophy Syndrome Deafness Syndrome, Progressive, With Blindness, Dystonia, Fractures, And Mental Deficiency Opticoacoustic Nerve Atrophy With Dementia Dystonia-Deafness Syndrome Ddp Ddon Syndrome Mohr-Tranebjærg Syndrome Deafness Dystonia Optic Atrophy Syndrome Deafness Dystonia Optic Neuronopathy Syndrome Dystonia Deafness Syndrome Ddon Deafness - Dystonia - Optic Neuronopathy Syndrome Deafness-Dystonia-Optic Neuronopathy Syndrome Hearing Loss-Dystonia-Optic Neuronopathy Syndrome Dfn-1 X-Linked Progressive Deafness Type 1
Myoclonic Epilepsy, Juvenile 3	Myoclonic Epilepsy, Juvenile, Susceptibility To, 3 EJM3 Epilepsy, Juvenile Myoclonic 3 Juvenile Myoclonic Epilepsy 3
Sennetsu Fever	Sennetsu Ehrlichiosis Human Ehrlichial Infection, Sennetsu Type
Sengers Syndrome	Mitochondrial Dna Depletion Syndrome 10 Cardiomyopathy And Cataract Cataract And Cardiomyopathy MTDPS10 Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10 Senger Syndrome
Visual Cortex Disease	Visual Cortex Dysfunction Visual Cortex Disorder Visual Cortical Disorder Disease Of Visual Cortex
Visual Pathway Disease	Disorder Of Visual Pathways
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14536	TIMM9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22862	Timm9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29376	Timm9 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TIMM9	MGD	MGI:1353436
Bos taurus	TIMM9	VGNC	VGNC:55149
Canis familiaris	TIMM9	VGNC	VGNC:49625
Rattus norvegicus	TIMM9	RGD	RGD:621656
Others	TIMM9	NCBI