CLEC4D - C-type lectin domain family 4 member D Gene

Also Known as MCL; MPCL; CD368; CLEC6; CLEC-6; CLECSF8; Dectin-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 338339

About CLEC4D

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,513,503-8,531,696 (from NCBI)

This gene has 2 transcripts (splice variants), 770 orthologues and 14 paralogues. Biased expression in bone marrow (RPKM 17.6), appendix (RPKM 4.0) and 1 other tissue.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to Other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

CLEC4D Products (1)

mRNA Protein Name
NM_080387.5 NP_525126.2 C-type lectin domain family 4 member D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-mannose binding IDA
IDA: Inferred from direct assay
23911656 GOA
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
23911656 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23911656 GOA
Biological Process GO Annotation Evidence References Source
involved in antifungal innate immune response IDA
IDA: Inferred from direct assay
23911656 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
23911656 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC4D Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (102 - 208)

  • 0
  • 100
  • 200
  • 215 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 4 member D

  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8

Recombinant CLEC4D Proteins

Cat. No. Product Name Accession Purity
HY-P76834 CLEC4D Protein, Human (HEK293, His) Q8WXI8 (G52-N215) ≥ 90%, as determined by reducing SDS-PAGE.

CLEC4D Antibodies

Cat. No. Product Name Application Reactivity
HY-P84693 CD368 Antibody (YA4390) FC, ELISA Human
HY-P84693A CD368 Antibody (YA4390)(PBS only) FC, ELISA Human

Related Diseases

Diseases Alias
Subcutaneous Mycosis

  • Subcutaneous Fungal Disease
Phaeohyphomycosis

  • Infection By Dematiacious Fungi

  • Phaehyphomycosis

  • Phaeomycosis

  • Pheohyphomycosis

  • Infection By Dematiacious Fungi [Phaehyphomycosis]

  • Dematiaceous Fungal Infection
Blastomycosis

  • Gilchrist'S Disease

  • North American Blastomycosis

  • Blastomyces Dermatitidis Infection

  • Blastomycotic Infection

  • Infection By Blastomyces Dermatitidis

  • Gilchrist Disease

  • Chicago Disease

  • Chicago Disease Or Disorder

  • Blastomycosis, Unspecified

  • Blastomyces Infection
Chromoblastomycosis

  • Chromomycosis

  • Mossy Foot Disease

  • Verrucous Dermatitis

  • Fonseca Disease

  • Pedroso Disease

  • Drechslera Hawaiiensis

  • Drechslera Infection
Vulvovaginal Candidiasis

  • Candidiasis Of Vulva And Vagina

  • Candidiasis, Vulvovaginal

  • Candidal Vulvovaginitis

  • Candidal: Cervix

  • Monilial Vulvovaginitis

  • Candidiasis Vulvovaginal
Dermatophytosis

  • Tinea

  • Dermatophytosis, Unspecified

  • Ringworm

  • Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

  • Cutaneous Mycosis

  • Dermal Mycosis

  • Superficial Mycosis, Unspecified

  • Fungus Infection Of Skin

  • Skin Mycosis

  • Dermatitis Fungoid

  • Fungal Dermatitis

  • Fungal Dermatosis

  • Mycotic Infection Of Skin
Tinea Corporis

  • Dermatophytosis Of The Body

  • Dermatophytosis Of The Trunk
Cryptococcosis

  • Cryptococcus Neoformans Infection

  • Torulosis

  • Busse-Buschke'S Disease

  • Cryptococcal Infection

  • European Cryptococcosis

  • Torula

  • Infection By Cryptococcus Neoformans

  • Cryptococcosis Infection

  • European Blastomycosis

  • European Blastomycotic Infection

  • European Blastomycoses Infection

  • Torula Histolytica Infection
Primary Systemic Mycosis
Opportunistic Mycosis

  • Opportunistic Mycoses

  • Opportunistic Systemic Mycoses
Fungal Infectious Disease

  • Mycoses

  • Mycosis
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02793 CLEC4D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19771 Clec4d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26268 Clec4d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CLEC4D VGNC VGNC:60951
Macaca mulatta CLEC4D VGNC VGNC:71178
Bos taurus CLEC4D VGNC VGNC:27431
Mus musculus CLEC4D MGD MGI:1298389
Rattus norvegicus CLEC4D RGD RGD:1303339
Others CLEC4D NCBI