TRPM3 - transient receptor potential cation channel subfamily M member 3 Gene

Also Known as GON-2; MLSN2; LTRPC3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80036

About TRPM3

Cytogenetic location: 9q21.12-q21.13 Genomic coordinates (GRCh38): 9:70,529,060-71,446,971 (from NCBI)

This gene has 28 transcripts (splice variants), 224 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 3.0), brain (RPKM 0.8) and 2 other tissues.

Summary

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

TRPM3 Products (23)

mRNA Protein Name
NM_001007470.3 NP_001007471.1 transient receptor potential cation channel subfamily M member 3 isoform c
NM_001007471.4 NP_001007472.2 transient receptor potential cation channel subfamily M member 3 isoform k
NM_001366141.2 NP_001353070.1 transient receptor potential cation channel subfamily M member 3 isoform i
NM_001366142.2 NP_001353071.1 transient receptor potential cation channel subfamily M member 3 isoform j
NM_001366143.2 NP_001353072.1 transient receptor potential cation channel subfamily M member 3 isoform w
NM_001366144.2 NP_001353073.1 transient receptor potential cation channel subfamily M member 3 isoform l
NM_001366145.2 NP_001353074.1 transient receptor potential cation channel subfamily M member 3 isoform m
NM_001366146.2 NP_001353075.1 transient receptor potential cation channel subfamily M member 3 isoform n
NM_001366147.2 NP_001353076.1 transient receptor potential cation channel subfamily M member 3 isoform o
NM_001366148.2 NP_001353077.1 transient receptor potential cation channel subfamily M member 3 isoform p
NM_001366149.2 NP_001353078.1 transient receptor potential cation channel subfamily M member 3 isoform q
NM_001366150.2 NP_001353079.1 transient receptor potential cation channel subfamily M member 3 isoform r
NM_001366151.2 NP_001353080.1 transient receptor potential cation channel subfamily M member 3 isoform s
NM_001366152.2 NP_001353081.1 transient receptor potential cation channel subfamily M member 3 isoform t
NM_001366153.2 NP_001353082.1 transient receptor potential cation channel subfamily M member 3 isoform u
NM_001366154.2 NP_001353083.1 transient receptor potential cation channel subfamily M member 3 isoform v
NM_020952.6 NP_066003.3 transient receptor potential cation channel subfamily M member 3 isoform a
NM_024971.7 NP_079247.5 transient receptor potential cation channel subfamily M member 3 isoform b
NM_206944.5 NP_996827.3 transient receptor potential cation channel subfamily M member 3 isoform d
NM_206945.5 NP_996828.3 transient receptor potential cation channel subfamily M member 3 isoform e
NM_206946.5 NP_996829.3 transient receptor potential cation channel subfamily M member 3 isoform f
NM_206947.5 NP_996830.3 transient receptor potential cation channel subfamily M member 3 isoform g
NM_206948.4 NP_996831.1 transient receptor potential cation channel subfamily M member 3 isoform h

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
32343227 GOA
enables monoatomic cation channel activity IDA
IDA: Inferred from direct assay
15824111 GOA
Biological Process GO Annotation Evidence References Source
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
32427099 GOA
acts upstream of or within monoatomic cation transport IDA
IDA: Inferred from direct assay
15824111 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPM3 Protein Structure

Ion_trans

Ion_trans: Ion transport protein (934 - 1111)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1707 a.a.
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 3

  • long transient receptor potential channel 3

Related Diseases

Diseases Alias
Mulibrey Nanism

  • MUL

  • Muscle-Liver-Brain-Eye Nanism

  • Pericardial Constriction And Growth Failure

  • Perheentupa Syndrome

  • Mulibrey Growth Disorder

  • Mulibrey Nanism Syndrome

  • Pericardial Constriction With Growth Failure

  • Nanism Mulibrey
Retinal Dystrophy And Iris Coloboma With Or Without Congenital Cataract

  • Familial Progressive Retinal Dystrophy-Iris Coloboma-Congenital Cataract Syndrome

  • Retinal Dystrophy And Iris Coloboma With Or Without Cataract

  • RDICC
Autosomal Dominant Non-Syndromic Intellectual Disability
Luminal Breast Carcinoma B

  • Luminal B Breast Carcinoma
Dentin Sensitivity

  • Sensitive Dentin
Anterior Segment Dysgenesis 5

  • Anterior Segment Dysgenesis 5, Multiple Subtypes

  • ASGD5

  • Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Exocervical Carcinoma

  • Carcinoma Of Exocervix

  • Carcinoma Of The Exocervix
Familial Episodic Pain Syndrome

  • Feps
Episodic Pain Syndrome, Familial, 1

  • FEPS1

  • Familial Episodic Pain Syndrome With Predominantly Upper Body Involvement

  • Familial Episodic Pain Syndrome 1
Hyperhidrosis, Gustatory

  • Frey Syndrome

  • Gustatory Sweating

  • Auriculotemporal Nerve Syndrome

  • Gustatory Hyperhidrosis

  • Frey'S Syndrome

  • Sweating, Gustatory

  • HYPRG

  • Baillarger Syndrome

  • Hyperhidrosis Gustatory

  • Auriculotemporal Syndrome
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

  • Olmsted Syndrome

  • Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques

  • Palmoplantar And Periorificial Keratoderma

  • Olms
Otosclerosis

  • Otospongiosis
Mucolipidosis Iv

  • Mucolipidosis Type Iv

  • ML4

  • Sialolipidosis

  • Mucolipidosis Type 4

  • Ganglioside Sialidase Deficiency

  • Mliv

  • Ml Iv

  • Berman Syndrome

  • Ganglioside Neuraminidase Deficiency

  • Ml 4

  • Mucolipidosis 4

  • Type Iv Mucolipidosis

  • Gangliosidoses
Chronic Fatigue Syndrome

  • Myalgic Encephalomyelitis

  • Postviral Fatigue Syndrome

  • Cfs

  • Myalgic Encephalitis

  • Encephalomyelitis, Myalgic

  • Chronic Fatigue

  • Fatigue Syndrome, Chronic

  • Benign Myalgic Encephalomyelitis

  • Akureyri

  • Akureyri Disease

  • Cfs - [Chronic Fatigue Syndrome]

  • Epidemic Neuromyasthenia

  • Myalgic Encephalomyelitis Syndrome

  • Me - [Myalgic Encephalomyelitis]

  • Pvfs - [Postviral Fatigue Syndrome]

  • Neuromyasthenia

  • Iceland Disease

  • Icelandic Disease
Kabuki Syndrome 1

  • Kabuki Syndrome

  • Niikawa-Kuroki Syndrome

  • Kabuki Make-Up Syndrome

  • Kms

  • KABUK1

  • Kabuki Make Up Syndrome

  • Nks

  • Kabuki Makeup Syndrome

  • Kabuki Syndrome, Type 1
Cataract

  • Cataracts

  • Cat - [Cataract]

  • Cataract Form

  • Lens Opacity

  • Lens Opacities
Congenital Stationary Night Blindness

  • Night Blindness, Congenital Stationary

  • Congenital Essential Nyctalopia

  • Oguchi Disease

  • Blindness, Night, Stationary, Congenital
Autosomal Dominant Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult Type

  • Adpkd

  • Polycystic Kidney Diseases

  • Polycystic Kidney, Autosomal Dominant

  • Congenital Biliary Ectasias

  • Polycystic Kidney And Hepatic Disease 1

  • Polycystic Kidney Disease, Autosomal Dominant

  • Kidney, Polycystic, Disease, Autosomal Dominant

  • Adult Polycystic Kidney Disease

  • Polycystic Kidney, Adult Type

  • Apckd - [Autosomal Polycystic Kidney Disease]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17386 Rosiglitazone Modulator 99.94% Yes
HY-17386A Rosiglitazone hydrochloride Modulator 99.81% Yes
HY-17386B Rosiglitazone potassium Modulator 99.13% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-182466 Ponometrep Antagonist 99.28% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110220 CIM0216 Agonist 99.94% Unkown
HY-132187 Sphingosylphosphorylcholine Activator 99.50% Unkown
HY-108451 Ononetin Antagonist 99.54% Unkown
HY-W089922 D-erythro-Sphingosine hydrochloride Activator 99.95% Unkown
HY-18101 BD-1063 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRPM3 VGNC VGNC:79104
Canis familiaris TRPM3 VGNC VGNC:47874
Rattus norvegicus TRPM3 RGD RGD:1304888
Felis catus TRPM3 VGNC VGNC:66589
Bos taurus TRPM3 VGNC VGNC:55085
Mus musculus TRPM3 MGD MGI:2443101
Others TRPM3 NCBI