HNRNPLL - heterogeneous nuclear ribonucleoprotein L like Gene

Also Known as SRRF; HNRPLL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92906

About HNRNPLL

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:38,561,969-38,602,928 (from NCBI)

This gene has 12 transcripts (splice variants), 275 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 17.8), thyroid (RPKM 11.5) and 25 other tissues.

Summary

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine Phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]

HNRNPLL Products (2)

mRNA Protein Name
NM_001142650.2 NP_001136122.1 heterogeneous nuclear ribonucleoprotein L-like isoform 2
NM_138394.4 NP_612403.2 heterogeneous nuclear ribonucleoprotein L-like isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
18669861 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18669861 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of RNA splicing IDA
IDA: Inferred from direct assay
18669861 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNRNPLL Protein Structure

(78 - 130)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (185 - 242)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (352 - 407)

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  • 500
  • 542 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein L-like

  • stromal RNA regulating factor

HNRNPLL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
HNRNPLL Q8WVV9 P0DTD1-PRO_0000449620 SARS-CoV-2 P0DTD1-PRO_0000449620
BLI
34159380
Intra
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978
Y2H Array
29892012
Intra
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978
Validated Y2H
25416956
Intra
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978
Y2H Prey Pooling
25416956
Intra
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra
HNRNPLL Q8WVV9 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
25416956
Intra
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Validated Y2H
26871637
Intra
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Y2H Array
26871637
Intra
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
26871637
Intra
HNRNPLL Q8WVV9 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra
HNRNPLL Q8WVV9 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra
HNRNPLL Q8WVV9 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
25416956
Intra
HNRNPLL Q8WVV9 THAP1 Homo sapiens Q9NVV9
Validated Y2H
25416956
Intra
HNRNPLL Q8WVV9 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra
HNRNPLL Q8WVV9 DAB1 Homo sapiens O75553
Validated Y2H
25416956
Intra
HNRNPLL Q8WVV9 DAB1 Homo sapiens O75553
Y2H Array
25416956
Intra
HNRNPLL Q8WVV9 QKI Homo sapiens Q96PU8
Anti Tag CoIP
33961781
Intra
HNRNPLL Q8WVV9 QKI Homo sapiens Q96PU8
Validated Y2H
25416956
Intra
HNRNPLL Q8WVV9 BOLL Homo sapiens Q8N9W6
Y2H Array
31515488
Intra
HNRNPLL Q8WVV9 BOLL Homo sapiens Q8N9W6
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06275 HNRNPLL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HNRNPLL MGD MGI:1919942
Bos taurus HNRNPLL VGNC VGNC:29898
Rattus norvegicus HNRNPLL RGD RGD:1305861
Canis familiaris HNRNPLL VGNC VGNC:41733
Felis catus HNRNPLL VGNC VGNC:62827
Macaca mulatta HNRNPLL VGNC VGNC:73441
Others HNRNPLL NCBI