trans-ccc_R08
Based on 1 Customer Validation
trans-ccc_R08 (Compound 1-B) is a cccDNA inhibitor with anti-HBV activity, with an IC50 of 0.14 μM for HBeAg and an IC50 of 0.08 μM for HBsAg in in vitro assays. trans-ccc_R08 inhibits covalently closed circular DNA (cccDNA). trans-ccc_R08 is applicable to research related to hepatitis B virus infection.
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 2413192-49-9
- Formula: C22H19ClO6
- Molecular Weight:414.84
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
trans-ccc_R08 inhibits HBeAg production in HepDES19 cells with an IC50 of 0.14 μM[1].
trans-ccc_R08 inhibits HBsAg production in cryopreserved primary hepatocytes, with an IC50 of 0.08 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2413192-49-9
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Appearance Solid
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Molecular Weight 414.84
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Formula C22H19ClO6
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Color Off-white to light yellow
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SMILES
O=C1C=C(C2=CC=C(C=C2)OCCO[C@@H]3C[C@H](C3)C(O)=O)OC4=C(Cl)C=CC=C41
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (241.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4106 mL | 12.0528 mL | 24.1057 mL | 60.2642 mL |
| 5 mM | 0.4821 mL | 2.4106 mL | 4.8211 mL | 12.0528 mL | |
| 10 mM | 0.2411 mL | 1.2053 mL | 2.4106 mL | 6.0264 mL | |
| 15 mM | 0.1607 mL | 0.8035 mL | 1.6070 mL | 4.0176 mL | |
| 20 mM | 0.1205 mL | 0.6026 mL | 1.2053 mL | 3.0132 mL | |
| 25 mM | 0.0964 mL | 0.4821 mL | 0.9642 mL | 2.4106 mL | |
| 30 mM | 0.0804 mL | 0.4018 mL | 0.8035 mL | 2.0088 mL | |
| 40 mM | 0.0603 mL | 0.3013 mL | 0.6026 mL | 1.5066 mL | |
| 50 mM | 0.0482 mL | 0.2411 mL | 0.4821 mL | 1.2053 mL | |
| 60 mM | 0.0402 mL | 0.2009 mL | 0.4018 mL | 1.0044 mL | |
| 80 mM | 0.0301 mL | 0.1507 mL | 0.3013 mL | 0.7533 mL | |
| 100 mM | 0.0241 mL | 0.1205 mL | 0.2411 mL | 0.6026 mL |
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