c-Met-IN-12
c-Met-IN-12 (compound 4r) is an orally active, potent and selective type II c-Met kinase inhibitor, with an IC50 of 10.6 nM. c-Met-IN-12 displays high inhibitory effects (inhibition rate > 80% in 1 μM) against AXL, Mer and TYRO3 kinases. c-Met-IN-12 can be used a scaffold for further kinase selectivity enhancement. c-Met-IN-12 shows antitumor efficacy.
For research use only. We do not sell to patients.
- CAS No.: 2426675-70-7
- Formula: C34H29FN4O4
- Molecular Weight:576.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 10.6 nM (c-Met)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2426675-70-7
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Molecular Weight 576.62
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Formula C34H29FN4O4
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SMILES
CN(C1=CC=NC(NC2=CC(F)=C(C=C2)OC3=C4C=CC(OCC(C)(O)C)=CC4=NC=C3)=C1C5=O)C=C5C6=CC=CC=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Met-IN-12 Related Classifications
HY-147695 Related Classifications
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