2426675-70-7
Chemical Structure
c-Met-IN-12
- CAS. Nr.: 2426675-70-7
- Formula:C34H29FN4O4
- Molecular Weight:576.62
IUPAC Name: 5-((3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)amino)-1-methyl-3-phenyl-1,6-naphthyridin-4(1H)-one
InChIKey: XSKIQQGAWQLRPT-UHFFFAOYSA-N
SMILES: CN(C1=CC=NC(NC2=CC(F)=C(C=C2)OC3=C4C=CC(OCC(C)(O)C)=CC4=NC=C3)=C1C5=O)C=C5C6=CC=CC=C6
Biological Activity: c-Met-IN-12 (compound 4r) is an orally active, potent and selective type II c-Met kinase inhibitor, with an IC50 of 10.6 nM. c-Met-IN-12 displays high inhibitory effects (inhibition rate > 80% in 1 μM) against AXL, Mer and TYRO3 kinases. c-Met-IN-12 can be used a scaffold for further kinase selectivity enhancement. c-Met-IN-12 shows antitumor efficacy[1].
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c-Met-IN-12 | c-Met-IN-12 (compound 4r) is an orally active, potent and selective type II c-Met kinase inhibitor, with an IC50 of 10.6 nM. c-Met-IN-12 displays high inhibitory effects (inhibition rate > 80% in 1 μM) against AXL, Mer and TYRO3 kinases. c-Met-IN-12 can be used a scaffold for further kinase selectivity enhancement. c-Met-IN-12 shows antitumor efficacy. | |||||||||||||||||||||
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