PINX1 - PIN2 (TERF1) interacting telomerase inhibitor 1 Gene

Also Known as Gno1; LPTL; LPTS; Pxr1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54984

About PINX1

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:10,764,961-10,839,875 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 5.1), appendix (RPKM 4.5) and 25 other tissues.

Summary

Enables Telomerase RNA binding activity and Telomerase Inhibitor activity. Involved in several processes, including negative regulation of DNA biosynthetic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Acts upstream of or within telomere maintenance via Telomerase. Located in several cellular components, including chromosomal region; nuclear lumen; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

PINX1 Products (2)

mRNA Protein Name
NM_001284356.2 NP_001271285.1 PIN2/TERF1-interacting telomerase inhibitor 1 isoform 2
NM_017884.6 NP_060354.4 PIN2/TERF1-interacting telomerase inhibitor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11701125 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
18202258 GOA
enables telomerase RNA binding IDA
IDA: Inferred from direct assay
15381700 GOA
enables telomerase inhibitor activity IDA
IDA: Inferred from direct assay
11701125 GOA
enables telomerase inhibitor activity IMP
IMP: Inferred from mutant phenotype
21119197 GOA
Biological Process GO Annotation Evidence References Source
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
19393617 GOA
involved in negative regulation of G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
11701125 GOA
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
24415760 GOA
involved in negative regulation of telomere maintenance via telomerase IDA
IDA: Inferred from direct assay
11701125 GOA
involved in negative regulation of telomere maintenance via telomerase IMP
IMP: Inferred from mutant phenotype
21119197 GOA
involved in positive regulation of protein localization to nucleolus IDA
IDA: Inferred from direct assay
19265708 GOA
involved in positive regulation of telomeric DNA binding IDA
IDA: Inferred from direct assay
19265708 GOA
involved in protein localization to chromosome, telomeric region IMP
IMP: Inferred from mutant phenotype
22749911 GOA
involved in protein localization to nucleolus IDA
IDA: Inferred from direct assay
24415760 GOA
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
24415760 GOA
acts upstream of or within telomere maintenance via telomerase IDA
IDA: Inferred from direct assay
11701125 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
11701125 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
19393617 GOA
located in nuclear chromosome IDA
IDA: Inferred from direct assay
19393617 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
11701125 GOA
located in spindle IDA
IDA: Inferred from direct assay
19393617 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PINX1 Protein Structure

G-patch

G-patch: G-patch domain (27 - 69)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
Protein Preferred Names Protein Names

PIN2/TERF1-interacting telomerase inhibitor 1

  • 67-11-3 protein

PINX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PINX1 Q96BK5 TERT Homo sapiens O14746
Anti Bait CoIP
28255170
Intra
PINX1 Q96BK5 TERT Homo sapiens O14746
Anti Tag CoIP
28255170
Intra
PINX1 Q96BK5 UBL5 Homo sapiens Q9BZL1
Validated Y2H
32296183
Intra
PINX1 Q96BK5 TERF1 Homo sapiens P54274
Anti Tag CoIP
33961781
Intra
PINX1 Q96BK5 TERF1 Homo sapiens P54274
Pull Down
21044950
Intra
PINX1 Q96BK5 TERF1 Homo sapiens P54274
CoIP
11701125
Intra
PINX1 Q96BK5 TERF1 Homo sapiens P54274
IF
11701125
Intra
PINX1 Q96BK5 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra
PINX1 Q96BK5 TLK1 Homo sapiens Q9UKI8
Validated Y2H
32296183
Intra
PINX1 Q96BK5 NPM1 Homo sapiens P06748
Pull Down
28255170
Intra
PINX1 Q96BK5 NPM1 Homo sapiens P06748
Affinity Chrom
28255170
Intra
PINX1 Q96BK5 NPM1 Homo sapiens P06748
IF
28255170
Intra
PINX1 Q96BK5 NPM1 Homo sapiens P06748
Anti Bait CoIP
28255170
Intra
PINX1 Q96BK5 NPM1 Homo sapiens P06748
Anti Tag CoIP
28255170
Intra
PINX1 Q96BK5 NPM1 Homo sapiens P06748
Anti Bait CoIP
17353931
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 22

  • IBD22
Thrombophlebitis Migrans
Ulcerative Stomatitis

  • Stomatitis Ulcerative

  • Aphthous Stomatitis

  • Minor Oral Aphthous Ulceration
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10560 PINX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PINX1 VGNC VGNC:79362
Mus musculus PINX1 MGD MGI:1919650
Rattus norvegicus PINX1 RGD RGD:1566025
Bos taurus PINX1 VGNC VGNC:32905
Canis familiaris PINX1 VGNC VGNC:44569
Others PINX1 NCBI