PPP3CA - protein phosphatase 3 catalytic subunit alpha Gene

Also Known as CALN; CCN1; CNA1; CALNA; DEE91; IECEE; PPP2B; ACCIID; CALNA1; IECEE1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5530

About PPP3CA

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:101,023,418-101,347,526 (from NCBI)

This gene has 9 transcripts (splice variants), 229 orthologues, 12 paralogues and is associated with 6 phenotypes. Broad expression in brain (RPKM 54.0), prostate (RPKM 42.7) and 24 other tissues.

Summary

Enables several functions, including ATPase binding activity; Calmodulin binding activity; and calmodulin-dependent protein Phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; peptidyl-serine dephosphorylation; and response to calcium ion. Located in several cellular components, including cytosol; dendritic spine; and nucleoplasm. Part of Calcineurin complex. Colocalizes with cytoplasmic side of plasma membrane. Implicated in developmental and epileptic encephalopathy 91. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]

PPP3CA Products (3)

mRNA	Protein	Name
NM_000944.5	NP_000935.1	protein phosphatase 3 catalytic subunit alpha isoform 1
NM_001130691.2	NP_001124163.1	protein phosphatase 3 catalytic subunit alpha isoform 2
NM_001130692.2	NP_001124164.1	protein phosphatase 3 catalytic subunit alpha isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	15955804	GOA
enables calmodulin binding	EXP EXP: Inferred from Experiment	18384083	GOA
enables calmodulin binding	IDA IDA: Inferred from direct assay	11005320	GOA
enables calmodulin binding	IPI IPI: Inferred from physical interaction	18384083	GOA
enables calmodulin-dependent protein phosphatase activity	IDA IDA: Inferred from direct assay	18815128	GOA
enables calmodulin-dependent protein phosphatase activity	IMP IMP: Inferred from mutant phenotype	30254215	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	11005320	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8524402	GOA
enables protein dimerization activity	IPI IPI: Inferred from physical interaction	11005320	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	30718414	GOA
enables protein serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	30611118	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	19154138	GOA
involved in calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	15955804	GOA
involved in calcineurin-mediated signaling	IMP IMP: Inferred from mutant phenotype	11005320	GOA
involved in negative regulation of angiotensin-activated signaling pathway	IDA IDA: Inferred from direct assay	30718414	GOA
involved in peptidyl-serine dephosphorylation	IMP IMP: Inferred from mutant phenotype	30611118	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	21785830	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20422345	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22688515	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	18815128	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	18815128	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of calcineurin complex	IDA IDA: Inferred from direct assay	12218175	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15955804	GOA
colocalizes with cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	22343722	GOA
located in dendritic spine	IDA IDA: Inferred from direct assay	22343722	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15955804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP3CA Protein Structure

Metallophos

0
100
200
300
400
521 a.a.

Protein Preferred Names	Protein Names
protein phosphatase 3 catalytic subunit alpha	CAM-PRP catalytic subunit

PPP3CA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP3CA	Q08209	USP14	Homo sapiens	P54578	Anti Tag CoIP	19896943
Intra	PPP3CA	Q08209	GRB2	Homo sapiens	P62993	Peptide Array	17474147
Intra	PPP3CA	Q08209	GRB2	Homo sapiens	P62993	Y2H	21900206
Intra	PPP3CA	Q08209	C16orf74	Homo sapiens	Q96GX8	Y2H Pooling	16189514
Intra	PPP3CA	Q08209	C16orf74	Homo sapiens	Q96GX8	Y2H Prey Pooling	25416956
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	Validated Y2H	25416956
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	X-Ray Diffraction	8524402
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	Lumier	32814053
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	Anti Tag CoIP	33961781
Intra	PPP3CA	Q08209	PPP3R1	Homo sapiens	P63098	Lumier	37398436
Cross	PPP3CA	Q08209	Cacng8	Rattus norvegicus	Q8VHW5	Anti Bait CoIP	24418105

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPP3CA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76759	Calcineurin A/PPP3CA Protein, Human (sf9, His)	Q08209-1 (S2-Q521)	≥ 90%, as determined by reducing SDS-PAGE.

PPP3CA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82763	Calcineurin A Antibody (YA2508)	WB, ICC/IF, FC	Human, Mouse, Rat
HY-P85455	Calcineurin A Antibody (YA5147)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Arthrogryposis, Cleft Palate, Craniosynostosis, And Impaired Intellectual Development	ACCIID Craniosynostosis-Microretrognathia-Severe Intellectual Disability Syndrome
Developmental And Epileptic Encephalopathy 91	Epileptic Encephalopathy, Infantile Or Early Childhood, 1 IECEE1 DEE91 Infantile Or Early Childhood Epileptic Encephalopathy 1 Encephalopathy, Epileptic, Infantile Or Early Childhood, Type 1
Autosomal Dominant Non-Syndromic Intellectual Disability
Non-Specific Early-Onset Epileptic Encephalopathy	Undetermined Early-Onset Epileptic Encephalopathy Non-Specific Eoee Undetermined Eoee
Pancreatic Ductal Adenocarcinoma	Ductal Adenocarcinoma Of The Pancreas
Osteomyelitis
Cardiomyopathy, Familial Hypertrophic, 10	Hypertrophic Cardiomyopathy 10 CMH10 Cardiomyopathy, Hypertrophic, Mid-Left Ventricular Chamber Type, 2 Cardiomyopathy, Hypertrophic, 10 Cardiomyopathy, Familial Hypertrophic 10 Familial Hypertrophic Cardiomyopathy With Mid-Left Ventricular Chamber Type 2 Mvc2 Cardiomyopathy, Hypertrophic, Familial, Type 10
Endocardium Disease
Septic Arthritis	Infectious Arthritis Arthritis, Infectious Arthritis Septic Arthritis, Bacterial
Flying Phobia	Aerophobia
Muscle Hypertrophy	MSLHP Hypertrophy Hypertrophy, Muscle
Contractural Arachnodactyly, Congenital	Congenital Contractural Arachnodactyly Beals Syndrome CCA Beals-Hecht Syndrome Distal Arthrogryposis Type 9 Arthrogryposis, Distal, Type 9 Da9 Arachnodactyly, Contractural Beals Type Contractures, Multiple With Arachnodactyly Ear Anomalies-Contractures-Dysplasia Of Bone With Kyphoscoliosis Arthrogyroposis, Distal, Type 9 Distal Arthrogyropsis Type 9 Cca Syndrome Arachnodactyly
Cataract 6, Multiple Types	Ctpp1 Cataract 6 Multiple Types CTRCT6 Cataract, Posterior Polar, 1 Arcc2 Cataract, Age-Related Cortical, 2 Ctpa Ctpp Age Related Cortical Cataract 2 Posterior Polar Cataract 1 Posterior Polar Cataract, 1 Age-Related Cortical Cataract 2 Cataract Posterior Polar 1
Cornea Plana	Flat Cornea
Staphyloenterotoxemia	Staphylococcal Food Poisoning Staphylococcal Toxaemia Due To Food Staphyloenterotoxicosis
Benign Essential Hypertension
Infective Endocarditis	Bacterial Endocarditis Endocarditis, Infective Infectious Endocarditis Endocarditis Infective
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Commensal Bacterial Infectious Disease
Impetigo
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11023	PPP3CA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19521	Ppp3ca Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26016	Ppp3ca Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPP3CA	MGD	MGI:107164
Macaca mulatta	PPP3CA	VGNC	VGNC:76382
Canis familiaris	PPP3CA	VGNC	VGNC:44918
Rattus norvegicus	PPP3CA	RGD	RGD:3382
Bos taurus	PPP3CA	VGNC	VGNC:33265
Felis catus	PPP3CA	VGNC	VGNC:69019
Others	PPP3CA	NCBI