Cacng8 - calcium voltage-gated channel auxiliary subunit gamma 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140729

Summary

Voltage-dependent calcium channels couple membrane depolarization in a number of cellular processes. These activities are regulated by distinct channels composed of the pore-forming alpha-1 subunit and the modulatory beta, alpha-2/delta and gamma subunits. The protein encoded by this gene represents one of the gamma subunits. It is an integral membrane protein that is thought to stabilize the Calcium Channel in an inactive (closed) state. This gene is located in a cluster with two similar gamma subunit-encoding genes on chromosome 1. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Jul 2008]

Cacng8 Products (1)

mRNA Protein Name
NM_080696.2 NP_542427.1 voltage-dependent calcium channel gamma-8 subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ionotropic glutamate receptor binding IDA
IDA: Inferred from direct assay
12771129 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
24418105 RGD
enables protein phosphatase 2B binding IPI
IPI: Inferred from physical interaction
24418105 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
12771129 RGD
involved in regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
17880894 RGD
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
19265014 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
24418105 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12771129 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
12771129 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
24418105 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent calcium channel gamma-8 subunit

  • TARP gamma-8

  • calcium channel, voltage-dependent, gamma subunit 8

  • neuronal voltage-gated calcium channel gamma-8 subunit

  • transmembrane AMPAR regulatory protein gamma-8

Cacng8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Cacng8 Q8VHW5 PPP3CA Homo sapiens Q08209
Pull Down
24418105
Intra
Cacng8 Q8VHW5 Ppp3ca Rattus norvegicus P63329
Anti Bait CoIP
24418105
Intra
Cacng8 Q8VHW5 Ppp3ca Rattus norvegicus P63329
IF
24418105
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01815 CACNG8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacng8 NCBI NCBI:59283