Ppp3ca - protein phosphatase 3 catalytic subunit alpha Gene

Also Known as Calna1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24674

Summary

Enables Calmodulin binding activity and calmodulin-dependent protein Phosphatase activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of Insulin secretion; and response to amphetamine. Located in cytosol. Part of Calcineurin complex. Is active in synapse. Colocalizes with slit diaphragm. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein Phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3ca Products (1)

mRNA Protein Name
NM_017041.2 NP_058737.1 protein phosphatase 3 catalytic subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
12135494 RGD
enables calmodulin binding IDA
IDA: Inferred from direct assay
12135494 RGD
enables calmodulin-dependent protein phosphatase activity IDA
IDA: Inferred from direct assay
24018048 RGD
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
1322410 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10593895 RGD
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
12135494 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
12135494 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
19965390 RGD
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
19965390 RGD
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
1322410 RGD
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
21273244 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
11954050 RGD
Cellular Component GO Annotation Evidence References Source
part of calcineurin complex IDA
IDA: Inferred from direct assay
12135494 RGD
located in slit diaphragm IDA
IDA: Inferred from direct assay
27009276 RGD
is active in synapse IDA
IDA: Inferred from direct assay
1313851 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 3 catalytic subunit alpha

serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

  • CAM-PRP catalytic subunit

  • CNA alpha

  • Calcineurin subunit A alpha

  • calcineurin A alpha

  • protein phosphatase 3, catalytic subunit, alpha isozyme

  • protein phosphatase-2Ba

Ppp3ca Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ppp3ca P63329 Cacna1c Rattus norvegicus P22002
Phosphatase Assay
19478199
Intra
Ppp3ca P63329 Cacna1c Rattus norvegicus P22002
CoIP
19478199
Intra
Ppp3ca P63329 Cacng8 Rattus norvegicus Q8VHW5
Anti Bait CoIP
24418105
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11023 PPP3CA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19521 Ppp3ca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26016 Ppp3ca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp3ca NCBI NCBI:5530