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Cat. No.: HY-164765

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NLRP3-IN-56

NLRP3-IN-56 (compound 062) is a NLRP3 inhibitor. NLRP3-IN-56 potently inhibits the level of IL-1β secretion by THP-1 cells with an IC₅₀ of 9.7 nM. NLRP3-IN-56 can be used for the study of NLRP3-mediated symptoms and/or diseases.

For research use only. We do not sell to patients.

CAS No.: 3048421-42-4
Formula: C₂₀H₁₈ClN₃O₃
Molecular Weight:383.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NLRP3-IN-56 Chemical Structure

CAS No.: 3048421-42-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All NOD-like Receptor (NLR) Isoforms :

Chemical Information

CAS No. 3048421-42-4
Molecular Weight 383.83
Formula C₂₀H₁₈ClN₃O₃
SMILES

OC1=CC(Cl)=CC=C1C(N=N2)=C3C(C=C(C#CC)C=C3)=C2NC[C@H](O)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fanglong Yang, et al. Pyridazine nlrp3 inhibitor compound, pharmaceutical composition, and preparation method therefor and use thereof. WO2024140824A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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NLRP3-IN-56

All NOD-like Receptor (NLR) Isoforms