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Cat. No.: HY-N11872

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Suffruticosol A

Suffruticosol A is a neuroprotective agent that restores scopolamine-induced cellular neurodegenerative damage. Suffruticosol A ameliorates hippocampal cholinergic deficits and partially enhances BDNF signaling. Suffruticosol A has neuromodulatory effects in a Scopolamine (HY-N0296)-induced model, restoring memory and cognitive performance in mice. Suffruticosol A can be isolated from seeds of P. lactiflora.

For research use only. We do not sell to patients.

CAS No.: 220936-82-3
Formula: C₄₂H₃₂O₉
Molecular Weight:680.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Suffruticosol A Chemical Structure

CAS No.: 220936-82-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

BDNF^[1]

In Vitro

Suffruticosol A (20 μM; 24 h) recovers cell viability and survival on human neuroblastoma SH-SY5Y cells against Scopolamine treatment (2 mM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Suffruticosol A (4 or 15 ng, twice a week; injected into third ventricle of the brain) improves neuronal effects in Scopolamine (1.0 mg/kg; ip) induced impairments of cognition and memory in mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 220936-82-3
Molecular Weight 680.70
Formula C₄₂H₃₂O₉
SMILES

OC1=CC(O[C@@H]2C3=CC=C(C=C3)O)=C4[C@@]2([H])C5=CC(O)=CC(O)=C5[C@@H](C6=CC=C(C=C6)O)[C@]7([H])C4=C1[C@@H](C8=CC(O)=CC(O)=C8)[C@@H]7C9=CC=C(C=C9)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim JH, et al. Enhanced neuronal activity by suffruticosol A extracted from Paeonia lactiflora via partly BDNF signaling in scopolamine-induced memory-impaired mice. Sci Rep. 2023 Jul 20;13(1):11731. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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