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United States

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製品番号: HY-145973

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3'OMe-m7GpppAmpG

(別名: m7(3'OMeG)(5')ppp(5')(2'OMeA)pG)

3’OMe-m7GpppAmpG (m7(3'OMeG)(5')ppp(5')(2'OMeA)pG) is a trinucleotide Cap1 analog with the structure m7 (3'OMeG)(5') ppp (5')(2'OMeA) pG, and also functions as a cis-acting ligase ribozyme inhibitor. 3’OMe-m7GpppAmpG effectively reduces free 5'-triphosphate groups on RNA transcripts, thereby enabling efficient co-transcriptional capping of in vitro transcribed mRNA. 3’OMe-m7GpppAmpG is not only widely used in the preparation of modified mRNA including trivalent influenza vaccine candidates, but also applicable to studies related to SARS-CoV-2 infection and other relevant research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2089461-55-0
分子式: C₃₃H₄₅N₁₅O₂₄P₄
分子量:1159.69

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

3'OMe-m7GpppAmpG 構造式

CAS 番号: 2089461-55-0

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

3’OMe-m7GpppAmpG (4 mM; 2 h) supports the production of translationally active HA-encoding mRNA that expresses functional HA protein in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2089461-55-0
分子量 1159.69
分子式 C₃₃H₄₅N₁₅O₂₄P₄
SMILES

O[C@@H]1[C@H](OC)[C@@H](COP(OP(OP(OC[C@@H]2[C@@H](OP([O-])(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(N=C(N)NC5=O)=C5N=C4)O3)=O)[C@@H](OC)[C@H](N6C(N=CN=C7N)=C7N=C6)O2)(O)=O)(O)=O)(O)=O)O[C@H]1N8C(N=C(N)NC9=O)=C9[N+](C)=C8
別名

m7(3'OMeG)(5')ppp(5')(2'OMeA)pG
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Mazunina EP, et al. Trivalent mRNA vaccine-candidate against seasonal flu with cross-specific humoral immune response. Front Immunol. 2024;15:1381508. Published 2024 Apr 16. [Content Brief]

[2]. Su C I, et al. A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning[J]. Nature Communications, 2024, 15(1): 6607.

[3]. Tusup M, et al. Design of in vitro transcribed mRNA vectors for research and therapy[J]. Chimia, 2019, 73(5): 391-391.

[4]. Kim S, et al. Innate immune responses against mRNA vaccine promote cellular immunity through IFN-β at the injection site[J]. Nature communications, 2024, 15(1): 7226.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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