4-Chlorochalcone
Based on 1 Customer Validation
4-Chlorochalcone (Compound 3) is a monoamine oxidase inhibitor (hMAO-B: IC50 = 0.082 μM, hMAO-A: IC50 = 9.95 μM). 4-Chlorochalcone also exhibits inhibitory activity against cholinesterase (AChE: IC50 = 2.79 μM). 4-Chlorochalcone is a chalcone derivative.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 956-04-7
- 分子式: C15H11ClO
- 分子量:242.70
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAL-51 | GI50 |
5.85 μM
Compound: SSE14105
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Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay
Antiproliferative activity against human CAL51 cells assessed as growth inhibition after 3 days by SRB assay
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[PMID: 28743509] |
| HCT-116 | GI50 |
16.54 μM
Compound: SSE14105
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Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay
Antiproliferative activity against human HCT116 cells assessed as growth inhibition after 3 days by SRB assay
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[PMID: 28743509] |
| HepG2 | IC50 |
97.2 μM
Compound: 2
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Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
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[PMID: 22658085] |
| Neutrophil | IC50 |
5.3 μM
Compound: 2
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| Neutrophil | IC50 |
5.4 μM
Compound: 2
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| RBL-1 | IC50 |
85 μM
Compound: 20
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Inhibition of 5-lipoxygenase in rat RBL1 cells
Inhibition of 5-lipoxygenase in rat RBL1 cells
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10.1007/s00044-013-0745-7 |
化学情報
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CAS 番号 956-04-7
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性状 Solid
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分子量 242.70
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分子式 C15H11ClO
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Color Off-white to light yellow
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SMILES
O=C(C=CC1=CC=C(Cl)C=C1)C=2C=CC=CC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
純度とドキュメンテーション
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データシート (265 KB)
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SDS (252 KB)
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- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
4-Chlorochalcone 関連分類
HY-W325160 関連分類
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