Furaltadone hydrochloride
Based on 1 publication(s) in Google Scholar
Furaltadone hydrochloride is an orally active antibacterial agent that can be used for the study of intestinal Salmonella infections. Furaltadone has in vitro inhibitory effects on Staphylococcus. In addition, Furaltadone shows inhibitory effects on allergic reactions.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.46%
- CAS 番号: 3759-92-0
- 分子式: C13H17ClN4O6
- 分子量:360.75
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 Furaltadone hydrochloride
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生物活性
Furaltadone (10 µM, 30 minutes) inhibits antigen-induced mast cell degranulation in RBL-2H3 and BMMC cells by suppressing the Lyn/Syk signaling pathway, with an IC50 of approximately 3.9 µM[3]. Furaltadone (10 µM, 30 minutes) inhibits antigen-induced phosphorylation of signaling proteins in RBL-2H3 and BMMC cells, suppressing mast cell activation with no cytotoxic effects[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RBL-2H3 (Rat Basophilic Leukemia) and bone marrow-derived mast cells (BMMCs)
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Concentration:10 µM
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Incubation Time:30 min
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Result:Inhibited the phosphorylation of early signaling proteins including Syk and LAT, and downstream signaling proteins Akt, Erk1/2, p38, and JNK in mast cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:IgE-mediated passive cutaneous anaphylaxis (PCA) in BALB/c mice[3]
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Dosage:3、10、30 mg/kg
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Administration:Oral gavage (p.o.), single dose
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Result:Significantly inhibited the allergic response in a dose-dependent manner and reduced mast cell degranulation in the skin.
化学情報
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CAS 番号 3759-92-0
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性状 Solid
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分子量 360.75
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分子式 C13H17ClN4O6
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Color Light yellow to yellow
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SMILES
O=C1OC(CN2CCOCC2)CN1/N=C/C3=CC=C([N+]([O-])=O)O3.[H]Cl
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別名
Altafur hydrochloride
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380
溶剤 & 溶解度
H2O : ≥ 25 mg/mL (69.30 mM)
DMSO : 16.67 mg/mL (46.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.67 mg/mL (4.63 mM); Clear solution
This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.67 mg/mL (4.63 mM); Clear solution
This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
純度とドキュメンテーション
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参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.7720 mL | 13.8600 mL | 27.7200 mL | 69.3001 mL |
| 5 mM | 0.5544 mL | 2.7720 mL | 5.5440 mL | 13.8600 mL | |
| 10 mM | 0.2772 mL | 1.3860 mL | 2.7720 mL | 6.9300 mL | |
| 15 mM | 0.1848 mL | 0.9240 mL | 1.8480 mL | 4.6200 mL | |
| 20 mM | 0.1386 mL | 0.6930 mL | 1.3860 mL | 3.4650 mL | |
| 25 mM | 0.1109 mL | 0.5544 mL | 1.1088 mL | 2.7720 mL | |
| 30 mM | 0.0924 mL | 0.4620 mL | 0.9240 mL | 2.3100 mL | |
| 40 mM | 0.0693 mL | 0.3465 mL | 0.6930 mL | 1.7325 mL | |
| H2O | 50 mM | 0.0554 mL | 0.2772 mL | 0.5544 mL | 1.3860 mL |
| 60 mM | 0.0462 mL | 0.2310 mL | 0.4620 mL | 1.1550 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Furaltadone hydrochloride 関連分類
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