H3B-8800
Based on 1 Customer Validation
H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.85%
- CAS 番号: 1825302-42-8
- 分子式: C31H45N3O6
- 分子量:555.71
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
SF3B splicing[1]
H3B-8800 (0.1-10000 nM; 72 h) inhibits cell growth in SF3B1-mutant cell line Panc05.04 cells[1].
H3B-8800 (0.1-10000 nM; 24 h) induces apoptosis in SF3B1-mutant cell line Panc05.04 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SF3B1-mutant cell line Panc05.04 cells
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Concentration:0.1,1, 10, 100, 1000, 10000 nM
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Incubation Time:24 h
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Result:Induced apoptosis by increased caspase-3/7 cleavage in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks, female NSG or CB17-SCID mice (K562 cells with SF3B1WT or SF3B1K700E)[1]
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Dosage:2, 4 mg/kg
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Administration:P.o.; daily
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Result:Resulted in antileukemic efficacy and splicing modulation in mice bearing AML patient-derived xenografts (PDXs) with a mutation in SF3B1 but had little effect in mice bearing SF3B1WT AML PDXs, significantly reduced leukemic burden relative in SF3B1K700E PDX.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1825302-42-8
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性状 Solid
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分子量 555.71
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分子式 C31H45N3O6
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SMILES
O=C(N1CCN(C)CC1)O[C@H]([C@](C)(O)CC[C@@H](O)C2)/C=C/[C@H](C)[C@H](OC2=O)/C(C)=C/C=C/[C@@H](C)C3=NC=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (179.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7995 mL | 8.9975 mL | 17.9950 mL | 44.9875 mL |
| 5 mM | 0.3599 mL | 1.7995 mL | 3.5990 mL | 8.9975 mL | |
| 10 mM | 0.1799 mL | 0.8997 mL | 1.7995 mL | 4.4987 mL | |
| 15 mM | 0.1200 mL | 0.5998 mL | 1.1997 mL | 2.9992 mL | |
| 20 mM | 0.0900 mL | 0.4499 mL | 0.8997 mL | 2.2494 mL | |
| 25 mM | 0.0720 mL | 0.3599 mL | 0.7198 mL | 1.7995 mL | |
| 30 mM | 0.0600 mL | 0.2999 mL | 0.5998 mL | 1.4996 mL | |
| 40 mM | 0.0450 mL | 0.2249 mL | 0.4499 mL | 1.1247 mL | |
| 50 mM | 0.0360 mL | 0.1799 mL | 0.3599 mL | 0.8997 mL | |
| 60 mM | 0.0300 mL | 0.1500 mL | 0.2999 mL | 0.7498 mL | |
| 80 mM | 0.0225 mL | 0.1125 mL | 0.2249 mL | 0.5623 mL | |
| 100 mM | 0.0180 mL | 0.0900 mL | 0.1799 mL | 0.4499 mL |
H3B-8800 関連分類
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