AChE-IN-29
AChE-IN-29, 3-OH pyrrolidine derivative, is an cholinesterase (ChE) inhibitor. AChE-IN-29 has cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC50 values of 0.25 μM, 0.23 μM and 0.72 μM, respectively. AChE-IN-29 can be used for the research of Alzheimer's disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3041113-91-8
- 分子式: C18H19BrN2O2
- 分子量:375.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 0.25 μM (hAChE); 0.23 μM (eeAChE); eqBChE (0.72 μM); 24.12 μM (in DPPH assay)[1]
AChE-IN-29 (VA10) can effectively inhibit the AChE, BChE and Aβ1-42[1].
AChE-IN-29 has Cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC50 values of 0.25 μM, 0.23 μM and 0.72 μM, respectively[1].
AChE-IN-29 has significant antioxidant activity with IC50 value of 24.12 μM in DPPH assay[1].
AChE-IN-29 (5 μM, 10 μM, 20 μM) can inhibit self-induced Aβ1-42 aggregation as well as hAChE-induced Aβ1-42 aggregation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y cells
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Concentration:5, 10, and 20 μM
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Incubation Time:72 h
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Result:Reduced the Aβ1-42 aggregation and showed no toxic effects on tested cell line (SH-SY5Y).
AChE-IN-29 (p.o.; 10 mg/kg) recovers cell density in hippocampus region[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (200 ± 15 g)[1]
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Dosage:2.5, 5, and 10 mg/kg
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Administration:p.o.; once a day for seven days
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Result:Improved cognition and memory in the scopolamine-induced cholinergic deficit.
Restoresd the neuronal cells and can inhibit neuronal toxicity in AD conditions.
化学情報
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CAS 番号 3041113-91-8
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分子量 375.26
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分子式 C18H19BrN2O2
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SMILES
O=C(C1=CC=C(C=C1)Br)NC2=CC=CC=C2CN3CC[C@@H](C3)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AChE-IN-29 関連分類
HY-149817 関連分類
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