ANO1-IN-2
ANO1-IN-2 (Compound 10q) is a selective ANO1 channel blocker with an IC50 of 1.75 μM and 7.43 μM against ANO1 and ANO2, respectively. ANO1-IN-2 suppresses strongly proliferation of glioblastoma cells.
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- CAS 番号: 637314-12-6
- 分子式: C16H14ClN3O2S2
- 分子量:379.88
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 1.75 μM (ANO1), 7.43 μM (ANO2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Astrocyte | GI50 |
45.15 μM
Compound: 10q
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Antiproliferative activity against mouse primary astrocytes assessed as reduction in cell viability measured after 72 hrs by Celltiter-Glo luminescent assay
Antiproliferative activity against mouse primary astrocytes assessed as reduction in cell viability measured after 72 hrs by Celltiter-Glo luminescent assay
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[PMID: 32906067] |
| U138-MG | GI50 |
13.22 μM
Compound: 10q
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Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
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[PMID: 32906067] |
| U-251 | GI50 |
12.04 μM
Compound: 10q
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Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
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[PMID: 32906067] |
| U-87MG ATCC | GI50 |
23.77 μM
Compound: 10q
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Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
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[PMID: 32906067] |
ANO1-IN-2 (Compound 10q) (10 μM) significantly suppresses migration and invasion of U251 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 637314-12-6
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分子量 379.88
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分子式 C16H14ClN3O2S2
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SMILES
NC(C1=C(SC2=C1CCC2)NC(NC(C3=CC=C(C=C3)Cl)=O)=S)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ANO1-IN-2 関連分類
HY-146321 関連分類
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