Antibacterial agent 127
Antibacterial agent 127 (Compound 23) is a potent antibacterial agent.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C28H37N3O5S
- 分子量:527.68
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Bacterial[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
>100 μM
Compound: 23
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Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
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[PMID: 36462445] |
Antibacterial agent 127 (Compound 23) (0-64 μg/mL; 20 h) shows antibacterial activity with MICs of 0.063, 0.063, 0.063, 0.25, 32 and 64 μg/mL against MSSA ATCC29213, MSSA ATCC25923, MRSAb, MRSEb, E.coli ATCC25922 and S.pullorum, respectively. And shows low cytotoxicity to RAW 264.7 cells (IC50＞100 μM)[1].
Antibacterial agent 127 shows good metabolic stability (t1/2 = 3.25 min in rat liver microsomes)[1].
Antibacterial agent 127 exhibits moderate inhibition effect on CYP3A4 (Midazolam) and CYP3A4 (Testosterone), with IC50 values of 2.64 and 1.94 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Kunming mice, neutropenic mouse thigh infection model[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection, single dose
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Result:Reduced bacteria count with a value of 1.84 log10 CFU/mL in comparison with vehicle control group.
化学情報
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分子量 527.68
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分子式 C28H37N3O5S
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SMILES
C[C@]([C@@H](O)[C@@H]1C)(C[C@@H](OC(CSC(N2)=NC3=C(C=CN3)C2=O)=O)[C@@]4(C)[C@@]5([H])[C@]1(CCC5=O)CC[C@H]4C)C=C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antibacterial agent 127 関連分類
HY-151937 関連分類
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