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製品番号: HY-162695

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Antitumor agent-168

Antitumor agent-168 (compound 21b) disrupts the microtubule network in tumor cells leading to G2/M cell cycle arrest and apoptosis induction. Antitumor agent-168 inhibits MCF-7 growth with an IC₅₀ value of 1.4 nM.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₂H₂₂N₄O₃
分子量:390.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Antitumor agent-168 構造式

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.003 μM Compound: 21b	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
A2780/Taxol	IC₅₀	4.8 nM Compound: 21b	Antiproliferative activity against paclitaxel resistant human A2780/Taxol cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against paclitaxel resistant human A2780/Taxol cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
A549	IC₅₀	0.001 μM Compound: 21b	Antiproliferative activity against human A549 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human A549 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
A549/TR	IC₅₀	1.6 nM Compound: 21b	Antiproliferative activity against paclitaxel resistant human A549/Taxol cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against paclitaxel resistant human A549/Taxol cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
DU-145	IC₅₀	0.004 μM Compound: 21b	Antiproliferative activity against human DU-145 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human DU-145 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
HCT-116	IC₅₀	0.003 μM Compound: 21b	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
HeLa	IC₅₀	0.9 nM Compound: 21b	Antiproliferative activity against human HeLa assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
HT-29	IC₅₀	0.011 μM Compound: 21b	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MCF7	IC₅₀	0.001 μM Compound: 21b	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MDA-MB-231	IC₅₀	0.02 μM Compound: 21b	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MDA-MB-468	IC₅₀	0.01 μM Compound: 21b	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
MGC-803	IC₅₀	0.5 nM Compound: 21b	Antiproliferative activity against human MGC-803 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MGC-803 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
PANC-1	IC₅₀	0.004 μM Compound: 21b	Antiproliferative activity against human PANC-1 assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human PANC-1 assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
SK-OV-3	IC₅₀	0.8 nM Compound: 21b	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]
U-87MG ATCC	IC₅₀	0.015 μM Compound: 21b	Antiproliferative activity against human U-87 MG assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human U-87 MG assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 38996194]

化学情報

分子量 390.44
分子式 C₂₂H₂₂N₄O₃
SMILES

NC1=CC(C2=CC=C3C(N(C4=CC(OC)=C(OC)C(OC)=C4)C=N3)=N2)=CC=C1C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Fuhao Jiang, et al. Discovery of Novel Diaryl-Substituted Fused Heterocycles Targeting Katanin and Tubulin with Potent Antitumor and Antimultidrug Resistance Efficacy. J Med Chem. 2024 Jul 25;67(14) [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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