ASK1-IN-12
ASK1-IN-12 is an ASK1 inhibitor with an IC50 of 6.3 nM. ASK1-IN-12 inhibits TNF-α-induced activation of the ASK1-p38/JNK pathway. ASK1-IN-12 can reduce free fatty acid-induced cholesterol increase, lipid droplet accumulation and improves hepatocellular steatosis. ASK1-IN-12 can be used for the research of non-alcoholic steatohepatitis (NASH).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C24H22F3N9O
- 分子量:509.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
ASK1-IN-12 (Compound 20) (1-6 μM; 24 h) reduces total cholesterol, triglyceride, low-density lipoprotein cholesterol and lipid droplet accumulation and improves hepatocellular steatosis in free fatty acid-induced LO2 cells[1].
ASK1-IN-12 (1-1000 nM; 24 h) inhibits TNF-α-induced activation of the ASK1-p38/JNK pathway in HepG2 cells[1].
ASK1-IN-12 (0.5-5 μM; 24 h) exhibits no significant cytotoxicity to LO2 hepatocytes, with cell viability maintained above 80%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:1, 10, 100 and 1000 nM
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Incubation Time:24 h
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Result:Reducd the phosphorylation ratios of p-ASK1/ASK1, p-JNK/JNK, and p-p38/p38.
化学情報
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分子量 509.49
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分子式 C24H22F3N9O
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SMILES
O=C(NC1=CC=CC(C2=NN=CN2[C@H](C(F)(F)F)C)=N1)C3=NN4C=CC(C5=CN(C(C)C)N=C5)=CC4=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ASK1-IN-12 関連分類
HY-179517 関連分類
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