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ATG-031

4 Cited Publications
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Based on 4 publication(s) in Google Scholar

ATG-031 is a humanized anti-CD24 monoclonal antibody with high affinity and specificity. ATG-031 interacts with Siglec-10 expressed by tumor-associated macrophages. ATG-031 effectively stimulates macrophage-mediated phagocytosis and induces cancer cell destruction by blocking the anti-phagocytic surface proteins. ATG-031 can be used in the study of haematological malignancies as well as solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

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  • 純度: ≥99%
  • 分子量:146.305 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for ATG-031
  • Experimental Validation Results for ATG-031
  • Experimental Validation Results for ATG-031
  • ATG-031 Chemical Structure
    ATG-031 構造式
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最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Loaded CD24 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78913) on AHC2 biosensor, can bind ATG-031 with an affinity constant of 8.121E-09 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1×106 MCF-7 cells labelling CD24 (red) with ATG-031 (HY-P99176). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Biotinylated Human CD24, at 5 μg/mL (100 μL/well, HY-P78913) on streptavidin precoated (0.5 μg/well) plate, can bind Anti-CD24 Mab (HY-P99176). The ED50 for this effect is 2.899 ng/mL.

  • ATG-031 Chemical Structure
    1/16
  • ATG-031
  • Loaded CD24 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78913) on AHC2 biosensor, can bind ATG-031 with an affinity constant of 8.121E-09 M as determined in BLI assay.
  • Flow cytometric analysis of 1×106 MCF-7 cells labelling CD24 (red) with ATG-031 (HY-P99176). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Biotinylated Human CD24, at 5 μg/mL (100 μL/well, HY-P78913) on streptavidin precoated (0.5 μg/well) plate, can bind Anti-CD24 Mab (HY-P99176). The ED50 for this effect is 2.899 ng/mL.