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製品番号: HY-183835

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Autophagy-IN-10

Autophagy-IN-10 is an Autophagy inhibitor and an inhibitor of ATG5 interaction with other proteins, with an IC₅₀ value of 2.29 μM against ATG5-ATG16L1 and an IC₅₀ value of 3.68 μM against ATG5-TECAIR.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2841473-75-2
分子式: C₂₉H₂₀N₂O₆
分子量:492.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Autophagy-IN-10 構造式

CAS 番号: 2841473-75-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Autophagy-IN-10 (Compound 12a) inhibits the ATG5-ATG16L1 and ATG5-TECAIR protein-protein interactions with IC₅₀ values of 2.29 μM and 3.68 μM, respectively^[1].
Autophagy-IN-10 (20 μM; 6 h) reduces autophagy incidence in COS-7 cells to 5.88%, effectively inhibiting autophagy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay^[1]

Cell Line:

COS-7 cells
Concentration:

20 μM
Incubation Time:

6 h
Result:

Reduced autophagy incidence in COS-7 cells to 5.88%.

化学情報

CAS 番号 2841473-75-2
分子量 492.48
分子式 C₂₉H₂₀N₂O₆
SMILES

O=C(N(C(C1=CC=CC=C1)=C/2)CC3=CC=C(C=C3)C(O)=O)C2=C\C4=CC=C(C5=CC=C(C=C5)[N+]([O-])=O)O4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Xiang H, et al. Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein-Protein Interactions Involving Autophagy-Related 5. J Med Chem. 2023 Feb 23;66(4):2457-2476. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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