BAY-091
Based on 1 Customer Validation
BAY-091, a chemical probe, is a potent and highly selective inhibitor of the kinase PIP4K2A.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.45%
- CAS 番号: 2922280-34-8
- 分子式: C26H21FN4O2
- 分子量:440.47
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Kinase Inhibitor Library
HY-L009
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EBC-1 | IC50 |
30 μM
Compound: 60; BAY-091
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Antiproliferative activity against human EBC-1 cells harboring p53 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human EBC-1 cells harboring p53 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
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[PMID: 34699202] |
| NCI-H460 | IC50 |
>30 μM
Compound: 60; BAY-091
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Antiproliferative activity against human NCI-H460 cells harboring wild type p53 assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human NCI-H460 cells harboring wild type p53 assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
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[PMID: 34699202] |
| THP-1 | IC50 |
>30 μM
Compound: 60; BAY-091
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Antiproliferative activity against human THP-1 cells harboring p53 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human THP-1 cells harboring p53 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
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[PMID: 34699202] |
BAY-091 (1 μM, 24 h) reduces the production of Hb γ chain in K562 and KU812 cells. BAY-091 reduces the conversion of PtdIns5P into other phosphatidylinositols, increases its bioavailability, thereby affecting the chromatin structure[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2922280-34-8
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性状 Solid
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分子量 440.47
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分子式 C26H21FN4O2
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Color Light yellow to light brown
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SMILES
CC[C@@H](NC1=C(C#N)C(C2=CC=C(C3=CC=CC(C)=C3F)C=C2)=NC4=CN=CC=C14)C(O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (283.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2703 mL | 11.3515 mL | 22.7030 mL | 56.7576 mL |
| 5 mM | 0.4541 mL | 2.2703 mL | 4.5406 mL | 11.3515 mL | |
| 10 mM | 0.2270 mL | 1.1352 mL | 2.2703 mL | 5.6758 mL | |
| 15 mM | 0.1514 mL | 0.7568 mL | 1.5135 mL | 3.7838 mL | |
| 20 mM | 0.1135 mL | 0.5676 mL | 1.1352 mL | 2.8379 mL | |
| 25 mM | 0.0908 mL | 0.4541 mL | 0.9081 mL | 2.2703 mL | |
| 30 mM | 0.0757 mL | 0.3784 mL | 0.7568 mL | 1.8919 mL | |
| 40 mM | 0.0568 mL | 0.2838 mL | 0.5676 mL | 1.4189 mL | |
| 50 mM | 0.0454 mL | 0.2270 mL | 0.4541 mL | 1.1352 mL | |
| 60 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.9460 mL | |
| 80 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.7095 mL | |
| 100 mM | 0.0227 mL | 0.1135 mL | 0.2270 mL | 0.5676 mL |
BAY-091 関連分類
HY-139868 関連分類
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