CID 5951923
Based on 1 publication(s) in Google Scholar
CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC50 of 603 nM. CID 5951923 can inhibit proliferation of cancer cells in vitro.
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- 純度: 98.87%
- CAS 番号: 749872-43-3
- 分子式: C16H18N2O7S
- 分子量:382.39
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 CID 5951923
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生物活性
IC50: 603 nM (KLF5)[1]
CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner[1].
CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1[1].
CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DLD-1 and IEC-6 cells
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Concentration:0.001, 0.01, 0.1, 1, 10, 100 μM
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Incubation Time:48 h
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Result:Inhibited proliferation of DLD-1 cells with an IC50 of 1.6 μM.
化学情報
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CAS 番号 749872-43-3
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性状 Solid
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分子量 382.39
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分子式 C16H18N2O7S
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Color White to off-white
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SMILES
O=C(OCC(N(C)C(CC1)CS1(=O)=O)=O)/C=C/C2=CC=CC([N+]([O-])=O)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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iScience
Single-cell transcriptome atlas of male mouse pituitary across postnatal life highlighting its stem cell landscape. [Abstract]2025 Jan 6;28(2):111708. PMID: 39898054
溶剤 & 溶解度
DMSO : 10 mg/mL (26.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6151 mL | 13.0757 mL | 26.1513 mL | 65.3783 mL |
| 5 mM | 0.5230 mL | 2.6151 mL | 5.2303 mL | 13.0757 mL | |
| 10 mM | 0.2615 mL | 1.3076 mL | 2.6151 mL | 6.5378 mL | |
| 15 mM | 0.1743 mL | 0.8717 mL | 1.7434 mL | 4.3586 mL | |
| 20 mM | 0.1308 mL | 0.6538 mL | 1.3076 mL | 3.2689 mL | |
| 25 mM | 0.1046 mL | 0.5230 mL | 1.0461 mL | 2.6151 mL |
CID 5951923 関連分類
HY-W011044 関連分類
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