E/Z-FETPY
E/Z-FETPY is an organo-diiron(I) complex with strong cytotoxicity in cancer cell lines. E/Z-FETPY induces ferroptosis in low-differentiated cell lines, such as A2780 cells.
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- CAS 番号: 3056250-97-3
- 分子式: C22H24F3Fe2N2O5S2
- 分子量:629.25
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
E/Z-FETPY (72 h) shows cytotoxic potential that inhibits the growth of HCT 116, MCF7, and A2780 cells with IC50 values 4 μM, 2.1 μM, and 2.5 μM, respectively[1].
E/Z-FETPY (2.5 μM; 24-48 h) shows a time-dependent increase in iron uptake was detected upon incubation of A2780 cells. E/Z-FETPY suppresses hydrogen peroxide (H2O2) and peroxynitrite (O═NOO-) along with amplified production of superoxide anion (O2-) and nitric oxide (NO)[1].
FETPY (5 μM) induces significant morphological changes in murine B16-F1 and B16-F10 melanoma cells, leading to senescence and/or trans-differentiation into Schwann-like cells, thus significantly reducing their tumorigenic potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-12 weeks old C57BL/6 male or female mice injected with B16-F1 or B16-F10 cells[1]
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Dosage:4 mg/kg
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Administration:i.p.; once a day; for 3 weeks
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Result:Suppressed tumor growth in low- and high-grade syngeneic melanoma models.
化学情報
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CAS 番号 3056250-97-3
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分子量 629.25
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分子式 C22H24F3Fe2N2O5S2
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SMILES
FC(F)(S(=O)([O-])=O)F.C[s]c1[Fe]2([N]3=CC=C(N(C)C)C=C3)([])[Fe-]1([])([CH+]#O)C2=O.[+].C4CCCC4.C5CCCC5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
E/Z-FETPY 関連分類
HY-158336 関連分類
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