Erzotabart
Based on 1 Customer Validation
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.00%
- CAS 番号: 2430792-01-9
- 分子量:145.056 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
Human IgG1 kappa
Human
CD38
Erzotabart targets cell surface glycoprotein CD-38 and carries the E430G mutation. Erzotabart promotes antibody hexamer formation through the E430G mutation in the Fc segment, and exhibits immunomodulating and antineoplastic activities[2].
Erzotabart induces complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), trogocytosis, inhibits the cyclase activity of CD38, and increases the hydrolase activity with EC50s of 0.044 µg/mL, 0.29 ng/mL, 2.719-5.779 ng/mL, 8.79 ng/mL, 0.419 µg/mL and 0.335 µg/mL, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ly12638 xenograft mouse models[3]
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Dosage:0.1-10 mg/kg
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Administration:iv, once weekly for 3 weeks
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Result:Inhibited tumor growth.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Loaded Erzotabart on AHC2 biosensor, can bind CD38 Protein, Human (HEK293, C-His, HY-P70731A) with an affinity constant of 1.209E-09 M as determined in BLI assay. -
Flow Cytometry analysis of Raji cells labelling CD38 (red) with Erzotabart (anti-CD38) (HY-P990037). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
化学情報
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CAS 番号 2430792-01-9
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性状 Liquid
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分子量 145.056 kDa
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Color Colorless to light yellow
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SMILES
[Erzotabart]
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別名
GEN3014
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)