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製品番号: HY-155046

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FGFR4-IN-14

FGFR4-IN-14 (Compound 27i) is a FGFR4 inhibitor (IC₅₀: 2.4 nM. FGFR4-IN-14 inhibits the proliferation of V550L and N535K mutant strains, with IC₅₀s of 21 nM, 2.5 nM, 171 nM against huh7, BaF3/ETV6-FGFR4-V550L and BaF3/ETV6-FGFR4-N535K cells respectively. FGFR4-IN-14 has potent antitumor efficacy in the Huh7 xenograft model. FGFR4-IN-14 can be used for research of hepatocellular carcinoma (HCC).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3027827-02-4
分子式: C₂₇H₂₅Cl₂N₅O₂
分子量:522.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

FGFR4-IN-14 構造式

CAS 番号: 3027827-02-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	0.002 μM Compound: 27i	Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-V550L mutant measured after 24 to 48 hrs by MTT assay Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-V550L mutant measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
BaF3	IC₅₀	0.172 μM Compound: 27i	Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-N535K mutant measured after 24 to 48 hrs by MTT assay Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-N535K mutant measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
Hep 3B2	IC₅₀	0.038 μM Compound: 27i	Antiproliferative activity against human Hep3B cells measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human Hep3B cells measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
HepG2	IC₅₀	>5 μM Compound: 27i	Antiproliferative activity against human HepG2 cells measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
Huh-7	IC₅₀	21 nM Compound: 27i	Antiproliferative activity against human Huh-7 cells measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human Huh-7 cells measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]
L02	IC₅₀	>10 μM Compound: 27i	Antiproliferative activity against human L02 cells measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human L02 cells measured after 24 to 48 hrs by MTT assay	[PMID: 37437349]

化学情報

CAS 番号 3027827-02-4
分子量 522.43
分子式 C₂₇H₂₅Cl₂N₅O₂
SMILES

C=CC(NC1=CC2=C(C=C1C3=NNC4=C3C=C(O[C@@H](C5=C(Cl)C=NC=C5Cl)C)C=C4)CCN(C)C2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Yang Y, et al. Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants. Eur J Med Chem. 2023 Oct 5;258:115628. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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