Fonsartan
Fonsartan (HR720) is an AT1 receptor antagonist. Fonsartan can be used for the study of myocardial infarction (MI).
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- CAS 番号: 153235-15-5
- 分子式: C26H30K2N4O5S2
- 分子量:620.87
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Angiotensin Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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AT1 Receptor |
Fonsartan selectively inhibits AT1 receptors (mainly in the adrenal cortex (IC50 = 1.5 × 10-8 M)) while having a lower affinity for AT2 receptors (mainly in the adrenal medulla (IC50 = 1.4 × 10-6 M))[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A myocardial infarction (MI) model was induced in male normotensive Wistar rats (weighing 250-280 g) by ligating the left anterior descending coronary artery[1].
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Dosage:3 mg/kg
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Administration:S.c., once daily for 6 weeks
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Result:Administration at 30 min, 3 h, 24 h, and 7 d post-administration all inhibited myocardial hypertrophy.
Administration at 3 h and 24 h post-administration significantly reduced infarct size.
Limited effect on improving left ventricular dilation (LVD, LVC).
化学情報
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CAS 番号 153235-15-5
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分子量 620.87
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分子式 C26H30K2N4O5S2
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SMILES
O=C(C1=C(SC)N=C(CCCC)N1CC2=CC=C(C3=C(S(=O)(N([K])C(NCCC)=O)=O)C=CC=C3)C=C2)O[K]
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別名
HR 720
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Xia QG, et al. Significance of timing of angiotensin AT1 receptor blockade in rats with myocardial infarction-induced heart failure. Cardiovasc Res. 2001 Jan;49(1):110-7. [Content Brief]
[2]. Jin D, et al. Pharmacological profiles of a novel non-peptide angiotensin II type I receptor antagonist HR720 in vitro and in vivo. Jpn J Pharmacol. 1997 Nov;75(3):259-66. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Fonsartan 関連分類
HY-19224 関連分類
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