FOXM1-IN-1
Based on 1 Customer Validation
FOXM1-IN-1 is a potent FOXM1 inhibitor with an IC50 value of 2.65 µM. FOXM1-IN-1 shows antiproliferative activity. FOXM1-IN-1 decreases the the expression of FOXM1, PLK1, CDC25B protein.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.86%
- CAS 番号: 2864407-22-5
- 分子式: C23H30ClNO3
- 分子量:403.94
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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生物活性
IC50: 2.65 µM (FOXM1)[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
2.69 μM
Compound: S2
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 22 to 70 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 22 to 70 hrs by CCK-8 assay
|
[PMID: 36334454] |
| HepG2 | IC50 |
15.06 μM
Compound: S2
|
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 22 to 70 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 22 to 70 hrs by CCK-8 assay
|
[PMID: 36334454] |
| SK-OV-3 | IC50 |
2.65 μM
Compound: S2
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Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 22 to 70 hrs by CCK-8 assay
Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 22 to 70 hrs by CCK-8 assay
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[PMID: 36334454] |
| SK-OV-3 | IC50 |
65.43 μM
Compound: S2
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Cytotoxicity against human SK-OV-3 cells expressing low FOXM1 assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
Cytotoxicity against human SK-OV-3 cells expressing low FOXM1 assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
|
[PMID: 36334454] |
FOXM1-IN-1 (0-10 μg/mL; 24 h) decreases the the expression of FOXM1, PLK1, CDC25B protein in SKOV3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, HCT116 cells
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Concentration:0-100 µM
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Incubation Time:24 h
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Result:Showed antiproliferative activity with IC50s of 15.06, 2.69 µM for HepG2, HCT116 cells, respectively.
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Cell Line:SKOV3 cells
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Concentration:0-10 μg/mL
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Incubation Time:24 h
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Result:Decreased the expression of FOXM1, PLK1, CDC25B protein in a dose dependent manner.
化学情報
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CAS 番号 2864407-22-5
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性状 Solid
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分子量 403.94
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分子式 C23H30ClNO3
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Color White to off-white
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SMILES
ClC1=CC=C(C=C1)COC2=CC=C(C=C2)OCCOCCNC3CCCCC3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (247.56 mM; ultrasonic and warming and heat to 160°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.19 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (269 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4756 mL | 12.3781 mL | 24.7562 mL | 61.8904 mL |
| 5 mM | 0.4951 mL | 2.4756 mL | 4.9512 mL | 12.3781 mL | |
| 10 mM | 0.2476 mL | 1.2378 mL | 2.4756 mL | 6.1890 mL | |
| 15 mM | 0.1650 mL | 0.8252 mL | 1.6504 mL | 4.1260 mL | |
| 20 mM | 0.1238 mL | 0.6189 mL | 1.2378 mL | 3.0945 mL | |
| 25 mM | 0.0990 mL | 0.4951 mL | 0.9902 mL | 2.4756 mL | |
| 30 mM | 0.0825 mL | 0.4126 mL | 0.8252 mL | 2.0630 mL | |
| 40 mM | 0.0619 mL | 0.3095 mL | 0.6189 mL | 1.5473 mL | |
| 50 mM | 0.0495 mL | 0.2476 mL | 0.4951 mL | 1.2378 mL | |
| 60 mM | 0.0413 mL | 0.2063 mL | 0.4126 mL | 1.0315 mL | |
| 80 mM | 0.0309 mL | 0.1547 mL | 0.3095 mL | 0.7736 mL | |
| 100 mM | 0.0248 mL | 0.1238 mL | 0.2476 mL | 0.6189 mL |
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