GAK-IN-3
GAK-IN-3 is a cyclin G-associated kinase (GAK) inhibitor with an IC50 of 207 nM and a Ki of 66 nM. GAK-IN-3 inhibits kinase activity in the nanomolar range by binding to GAK’s ATP-binding site. GAK-IN-3 acts as a cytotoxic agent that reduces viability of Ewing sarcoma cells. GAK-IN-3 can be used for the research of ewing sarcoma.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C19H19N5S
- 分子量:349.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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GAK 207 nM (IC50) |
GAK 66 nM (Ki) |
GAK-IN-3 (compound 3c) (10 μM; 48 h) reduces RD‐ES cell viability to 25.7% and Daoy cell viability to 44.6%[1].
GAK-IN-3 (compound 3c) (0.225-7.2 μM; 48 h) inhibits RD‐ES cell viability with an IC50 of 1.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RD‐ES (Ewing Sarcoma), Daoy (medulloblastoma)
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Concentration:10 μM
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Incubation Time:48 h
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Result:Reduced RD‐ES cell viability to 25.7% and Daoy cell viability to 44.6% at 10 μM after 48 h incubation.
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Cell Line:RD‐ES
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Concentration:7.2, 3.6, 1.8,
0.9, 0.45, and 0.225 μM -
Incubation Time:48 h
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Result:Inhibited RD‐ES cell viability with an IC50 of 1.1 μM after 48 h incubation.
化学情報
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分子量 349.45
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分子式 C19H19N5S
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SMILES
S=C(N)N/N=C/C1=CC=NC2=CC=C(NC3=CC(C)=CC(C)=C3)C=C21
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GAK-IN-3 関連分類
HY-181169 関連分類
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