FUS - FUS RNA binding protein Gene
Also Known as TLS; ALS6; ETM4; FUS1; POMP75; altFUS; HNRNPP2
生物種: Homo sapiens
About FUS
This gene has 13 transcripts (splice variants), 181 orthologues, 2 paralogues and is associated with 87 phenotypes. Ubiquitous expression in appendix (RPKM 32.4), lymph node (RPKM 29.5) and 25 other tissues.
Summary
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/MicroRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
FUS Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001170634.1 | NP_001164105.1 | RNA-binding protein FUS isoform 2 |
| NM_001170937.1 | NP_001164408.1 | RNA-binding protein FUS isoform 3 |
| NM_004960.4 | NP_004951.1 | RNA-binding protein FUS isoform 1 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables RNA binding |
EXP
EXP: Inferred from Experiment
|
29677513 | GOA |
| enables RNA binding |
IDA
IDA: Inferred from direct assay
|
27378374 | GOA |
| enables RNA binding |
IPI
IPI: Inferred from physical interaction
|
38070499 | GOA |
| enables chromatin binding |
IDA
IDA: Inferred from direct assay
|
25453086 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
18509338 | GOA |
| enables molecular condensate scaffold activity |
EXP
EXP: Inferred from Experiment
|
38070499 | GOA |
| enables molecular condensate scaffold activity |
IDA
IDA: Inferred from direct assay
|
26317470 | GOA |
| enables molecular condensate scaffold activity |
IMP
IMP: Inferred from mutant phenotype
|
38070499 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9774382 | GOA |
| enables transcription coactivator activity |
IDA
IDA: Inferred from direct assay
|
21909421 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| is active in intracellular non-membrane-bounded organelle |
IDA
IDA: Inferred from direct assay
|
21541367 | GOA |
| is active in nucleoplasm |
IDA
IDA: Inferred from direct assay
|
38070499 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
16365397 | GOA |
FUS Protein Structure
RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (287 - 365)
zf-RanBP: Zn-finger in Ran binding protein and others (422 - 453)
- 0
- 100
- 200
- 300
- 400
- 500
- 526 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
RNA-binding protein FUS |
|
FUS Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
FUS | P35637 | RELA | Homo sapiens | Q04206-3 | 32814053 | |
|
Intra
|
FUS | P35637 | RELA | Homo sapiens | Q04206-3 | 32814053 | |
|
Intra
|
FUS | P35637 | RELA | Homo sapiens | Q04206-3 | 32814053 | |
|
Intra
|
FUS | P35637 | PBX4 | Homo sapiens | Q9BYU1 | 32814053 | |
|
Intra
|
FUS | P35637 | PBX4 | Homo sapiens | Q9BYU1 | 32814053 | |
|
Intra
|
FUS | P35637 | PBX4 | Homo sapiens | Q9BYU1 | 32814053 | |
|
Intra
|
FUS | P35637 | OTUB1 | Homo sapiens | Q96FW1 | 32814053 | |
|
Intra
|
FUS | P35637 | OTUB1 | Homo sapiens | Q96FW1 | 32814053 | |
|
Intra
|
FUS | P35637 | OTUB1 | Homo sapiens | Q96FW1 | 32814053 | |
|
Intra
|
FUS | P35637 | BAG6 | Homo sapiens | P46379-2 | 32814053 | |
|
Intra
|
FUS | P35637 | BAG6 | Homo sapiens | P46379-2 | 32814053 | |
|
Intra
|
FUS | P35637 | BAG6 | Homo sapiens | P46379-2 | 32814053 | |
|
Intra
|
FUS | P35637 | PTBP2 | Homo sapiens | Q9UKA9-2 | 32814053 | |
|
Intra
|
FUS | P35637 | PTBP2 | Homo sapiens | Q9UKA9-2 | 32814053 | |
|
Intra
|
FUS | P35637 | PTBP2 | Homo sapiens | Q9UKA9-2 | 32814053 | |
|
Intra
|
FUS | P35637 | GSK3B | Homo sapiens | P49841-2 | 32814053 | |
|
Intra
|
FUS | P35637 | GSK3B | Homo sapiens | P49841-2 | 32814053 | |
|
Intra
|
FUS | P35637 | GSK3B | Homo sapiens | P49841-2 | 32814053 | |
|
Intra
|
FUS | P35637 | PRMT1 | Homo sapiens | Q99873-3 | 23152885 | |
|
Intra
|
FUS | P35637 | PRMT1 | Homo sapiens | Q99873-3 | 23152885 | |
|
Intra
|
FUS | P35637 | PRMT1 | Homo sapiens | Q99873-3 | 23152885 | |
|
Intra
|
FUS | P35637 | TAF15 | Homo sapiens | Q92804 | 23975937 | |
|
Intra
|
FUS | P35637 | TAF15 | Homo sapiens | Q92804 | 27460707 | |
|
Intra
|
FUS | P35637 | TAF15 | Homo sapiens | Q92804 | 35271311 | |
|
Cross
|
FUS | P35637 | Crebbp | Mus musculus | P45481 | 18509338 | |
|
Intra
|
FUS | P35637 | PLEC | Homo sapiens | Q15149 | 22240165 | |
|
Intra
|
FUS | P35637 | PLEC | Homo sapiens | Q15149 | 22240165 | |
|
Cross
|
FUS | P35637 | Smn1 | Mus musculus | P97801 | 23681068 | |
|
Cross
|
FUS | P35637 | Smn1 | Mus musculus | P97801 | 23681068 | |
|
Intra
|
FUS | P35637 | SAFB | Homo sapiens | Q15424 | 27731383 | |
|
Intra
|
FUS | P35637 | SAFB | Homo sapiens | Q15424 | 27731383 | |
|
Intra
|
FUS | P35637 | SAFB | Homo sapiens | Q15424 | 27731383 | |
|
Intra
|
FUS | P35637 | SAFB | Homo sapiens | Q15424 | 27731383 | |
|
Intra
|
FUS | P35637 | SAFB | Homo sapiens | Q15424 | 27731383 | |
|
Intra
|
FUS | P35637 | SAFB | Homo sapiens | Q15424 | 35271311 | |
|
Intra
|
FUS | P35637 | RPP25 | Homo sapiens | Q9BUL9 | 32814053 | |
|
Intra
|
FUS | P35637 | RPP25 | Homo sapiens | Q9BUL9 | 32814053 | |
|
Intra
|
FUS | P35637 | RPP25 | Homo sapiens | Q9BUL9 | 32814053 | |
|
Intra
|
FUS | P35637 | TARDBP | Homo sapiens | Q13148 | 27615052 | |
|
Intra
|
FUS | P35637 | TARDBP | Homo sapiens | Q13148 | 27615052 | |
|
Intra
|
FUS | P35637 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
FUS | P35637 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
FUS | P35637 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
FUS | P35637 | TARDBP | Homo sapiens | Q13148 | 35271311 | |
|
Intra
|
FUS | P35637 | SMN1 | Homo sapiens | Q16637 | 23681068 | |
|
Intra
|
FUS | P35637 | SMN1 | Homo sapiens | Q16637 | 35271311 | |
|
Intra
|
FUS | P35637 | KAT5 | Homo sapiens | Q92993 | 18509338 | |
|
Intra
|
FUS | P35637 | KAT5 | Homo sapiens | Q92993 | 18509338 | |
|
Intra
|
FUS | P35637 | FUS | Homo sapiens | P35637 | 23975937 | |
|
Intra
|
FUS | P35637 | FUS | Homo sapiens | P35637 | 29439243 | |
|
Intra
|
FUS | P35637 | FUS | Homo sapiens | P35637 | 29610493 | |
|
Intra
|
FUS | P35637 | FUS | Homo sapiens | P35637 | 18509338 | |
|
Intra
|
FUS | P35637 | FUS | Homo sapiens | P35637 | 29610493 | |
|
Intra
|
FUS | P35637 | EP300 | Homo sapiens | Q09472 | 18509338 | |
|
Intra
|
FUS | P35637 | EP300 | Homo sapiens | Q09472 | 18509338 | |
|
Intra
|
FUS | P35637 | DROSHA | Homo sapiens | Q9NRR4 | 23232809 | |
|
Intra
|
FUS | P35637 | DROSHA | Homo sapiens | Q9NRR4 | 23232809 | |
|
Intra
|
FUS | P35637 | SPATA22 | Homo sapiens | Q8NHS9 | 32814053 | |
|
Intra
|
FUS | P35637 | SPATA22 | Homo sapiens | Q8NHS9 | 32814053 | |
|
Intra
|
FUS | P35637 | SPATA22 | Homo sapiens | Q8NHS9 | 32814053 | |
|
Intra
|
FUS | P35637 | RALY | Homo sapiens | Q9UKM9 | 35271311 | |
|
Intra
|
FUS | P35637 | EWSR1 | Homo sapiens | Q01844 | 23975937 | |
|
Intra
|
FUS | P35637 | EWSR1 | Homo sapiens | Q01844 | 21988832 | |
|
Intra
|
FUS | P35637 | RBMX | Homo sapiens | P38159 | 27460707 | |
|
Intra
|
FUS | P35637 | RBMX | Homo sapiens | P38159 | 35271311 | |
|
Intra
|
FUS | P35637 | CBLB | Homo sapiens | Q13191 | 32814053 | |
|
Intra
|
FUS | P35637 | CBLB | Homo sapiens | Q13191 | 32814053 | |
|
Intra
|
FUS | P35637 | CBLB | Homo sapiens | Q13191 | 32814053 | |
|
Intra
|
FUS | P35637 | RYBP | Homo sapiens | Q8N488 | 32814053 | |
|
Intra
|
FUS | P35637 | RYBP | Homo sapiens | Q8N488 | 32814053 | |
|
Intra
|
FUS | P35637 | RYBP | Homo sapiens | Q8N488 | 32814053 | |
|
Intra
|
FUS | P35637 | PRMT1 | Homo sapiens | Q99873 | 23152885 | |
|
Intra
|
FUS | P35637 | PRMT1 | Homo sapiens | Q99873 | 23152885 | |
|
Intra
|
FUS | P35637 | PRMT1 | Homo sapiens | Q99873 | 16169070 | |
|
Intra
|
FUS | P35637 | PRMT1 | Homo sapiens | Q99873 | 23152885 | |
|
Intra
|
FUS | P35637 | SEM1 | Homo sapiens | P60896 | 32814053 | |
|
Intra
|
FUS | P35637 | SEM1 | Homo sapiens | P60896 | 32814053 | |
|
Intra
|
FUS | P35637 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
FUS | P35637 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
FUS | P35637 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
FUS | P35637 | GRIN1 | Homo sapiens | Q05586 | 32814053 | |
|
Intra
|
FUS | P35637 | GRIN1 | Homo sapiens | Q05586 | 32814053 | |
|
Intra
|
FUS | P35637 | GRIN1 | Homo sapiens | Q05586 | 32814053 |
FUS 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P83452 | TLS/FUS Antibody (YA3197) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
| HY-P86540 | TLS/FUS Antibody (YA6232) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Tremor, Hereditary Essential, 4 |
|
|
| Amyotrophic Lateral Sclerosis 6 With Or Without Frontotemporal Dementia |
|
|
| Amyotrophic Lateral Sclerosis Type 6 |
|
|
| Juvenile Amyotrophic Lateral Sclerosis |
|
|
| Myxoid Liposarcoma |
|
|
| Myxofibrosarcoma |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Liposarcoma |
|
|
| Fibrous Histiocytoma |
|
|
| Lateral Sclerosis |
|
|
| Frontotemporal Dementia |
|
|
| Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 |
|
|
| Sarcoma |
|
|
| Mixed Liposarcoma |
|
|
| Clear Cell Sarcoma |
|
|
| Lipomatosis, Multiple |
|
|
| Myeloid Leukemia |
|
|
| Dementia |
|
|
| Spinocerebellar Ataxia 2 |
|
|
| Cellular Myxoid Liposarcoma |
|
|
| Tremor |
|
|
| Speech And Communication Disorders |
|
|
| Essential Tremor |
|
|
| Myxoid Liposarcoma Of The Ovary |
|
|
| Liposarcoma Of The Ovary |
|
|
| Multisystem Proteinopathy |
|
|
| Motor Neuron Disease |
|
|
| Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7 |
|
|
| Malignant Fibrous Histiocytoma |
|
|
| Well-Differentiated Liposarcoma |
|
|
| Leukemia |
|
|
| Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia |
|
|
| Ewing Sarcoma |
|
|
| Extraosseous Chondrosarcoma |
|
|
| Epithelial-Stromal Tgfbi Dystrophy |
|
|
| Chondrosarcoma, Extraskeletal Myxoid |
|
|
| Muscular Atrophy |
|
|
| Pleomorphic Liposarcoma |
|
|
| Amyotrophic Lateral Sclerosis 4, Juvenile |
|
|
| Amyotrophic Lateral Sclerosis 18 |
|
|
| Progressive Muscular Atrophy |
|
|
| Amyotrophic Lateral Sclerosis 21 |
|
|
| Lattice Corneal Dystrophy |
|
|
| Nominal Aphasia |
|
|
| Prosopagnosia |
|
|
| Pleomorphic Lipoma |
|
|
| Amyotrophic Lateral Sclerosis 11 |
|
|
| Progressive Bulbar Palsy |
|
|
| Amyotrophic Lateral Sclerosis 8 |
|
|
| Amyotrophic Lateral Sclerosis Type 14 |
|
|
| Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1 |
|
|
| Pick Disease Of Brain |
|
|
| Spinal And Bulbar Muscular Atrophy, X-Linked 1 |
|
|
| Ideomotor Apraxia |
|
|
| Fibrosarcoma |
|
|
| Spindle Cell Rhabdomyosarcoma |
|
|
| Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia |
|
|
| Aphasia |
|
|
| Dedifferentiated Liposarcoma |
|
|
| Perry Syndrome |
|
|
| Creutzfeldt-Jakob Disease |
|
|
| Locked-In Syndrome |
|
|
| Desmoplastic Small Round Cell Tumor |
|
|
| Kidney Fibrosarcoma |
|
|
| Myoepithelial Carcinoma |
|
|
| Supranuclear Palsy, Progressive, 1 |
|
|
| Amyotrophic Lateral Sclerosis Type 12 |
|
|
| Chondroid Lipoma |
|
|
| Malignant Inflammatory Fibrous Histiocytoma |
|
|
| Amyotrophic Lateral Sclerosis 16, Juvenile |
|
|
| Pseudobulbar Palsy |
|
|
| Synovium Cancer |
|
|
| X-Linked Hereditary Ataxia |
|
|
| Paget'S Disease Of Bone |
|
|
| Fragile X-Associated Tremor/Ataxia Syndrome |
|
|
| Dementia, Lewy Body |
|
|
| Rett Syndrome |
|
|
| Rhabdomyosarcoma |
|
|
| Movement Disease |
|
|
| Alveolar Soft Part Sarcoma |
|
|
| Autism Spectrum Disorder |
|
|
| Autosomal Dominant Cerebellar Ataxia |
|
|
| Sarcoma, Synovial |
|
|
| Hereditary Ataxia |
|
|
| Rhabdomyosarcoma 2 |
|
|
| Cerebellar Disease |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Giant Axonal Neuropathy 2 |
|
|
| Spinal Muscular Atrophy |
|
|
| Autism |
|
|
| Neuromuscular Disease |
|
|
| Hemochromatosis, Type 1 |
|
|
| Hereditary Spastic Paraplegia |
|
|
| Nervous System Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Charcot-Marie-Tooth Disease |
|
|
| Myopathy |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Mus musculus | FUS | MGD | MGI:1353633 |
| Rattus norvegicus | FUS | RGD | RGD:1308864 |
| Felis catus | FUS | VGNC | VGNC:62391 |
| Bos taurus | FUS | VGNC | VGNC:29147 |
| Canis familiaris | FUS | VGNC | VGNC:41011 |
| Macaca mulatta | FUS | VGNC | VGNC:72828 |
| Others | FUS | NCBI |