Dcc - DCC netrin 1 receptor Gene

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 25311

Summary

Enables identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of neuron projection development; and response to amphetamine. Located in growth cone membrane and membrane raft. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Dcc Products (1)

mRNA Protein Name
NM_012841.2 NP_036973.1 netrin receptor DCC precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables identical protein binding IPI
IPI: Inferred from physical interaction
18585357 RGD
enables netrin receptor activity IMP
IMP: Inferred from mutant phenotype
8861902 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15788770 RGD
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
12840034 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in axon development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in axon guidance IMP
IMP: Inferred from mutant phenotype
8861902 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in corpus callosum development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
15811950 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
15737744 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
17996376 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
located in axon IDA
IDA: Inferred from direct assay
12840034 RGD
located in growth cone membrane IDA
IDA: Inferred from direct assay
18691385 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

netrin receptor DCC

  • colorectal tumor suppressor

  • deleted in colorectal carcinoma

  • putative colorectal tumor suppressor

  • tumor suppressor protein DCC

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-112306 Ripretinib 98.90% Yes
HY-136256 Vimseltinib Inhibitor 99.94% Unkown

Clinical Phase

Bioactive Molecules (3)
製品番号 製品名 製品効果
純度 Phase
HY-13024 Rebastinib 99.84% Phase 2
HY-160699 DCC-3116 Inhibitor 99.84% Phase 2
HY-B0791 Altiratinib Inhibitor 99.29% Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-Y1092 N,N-Dicyclohexylcarbodiimide(DCC) Activator 99.75% Unkown
HY-W074890 Palmitoylglycine Modulator 99.84% Unkown
HY-W099632 2-Hexyldecanoic acid 99.71% Unkown
HY-D2751 BP Fluor 488 cadaverine 98.15% Unkown
HY-100855 DC_C66 Inhibitor / Unkown
HY-13024A Rebastinib tosylate / Unkown
HY-163008 Dicamba-5-aminopentanoic acid / Unkown
HY-RS03571 DCC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-157262 Methyl isonicotinate-(CH2)2-COOH / Unkown
HY-D2764 Difluorocarboxyfluorescein cadaverine, 5-isomer / Unkown
HY-D2765 BP Fluor 405 cadaverine / Unkown
HY-D2772 5-TAMRA Cadaverine / Unkown
HY-RS17183 Dcc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23634 Dcc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Dcc NCBI NCBI:1630