IL1RAPL2 - interleukin 1 receptor accessory protein like 2 Gene

Also Known as IL1R9; IL-1R9; TIGIRR-1; IL1RAPL-2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 26280

About IL1RAPL2

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:104,566,199-105,767,829 (from NCBI)

This gene has 3 transcripts (splice variants), 122 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic cognitive disability. [provided by RefSeq, Jul 2008]

IL1RAPL2 Products (1)

mRNA	Protein	Name
NM_017416.2	NP_059112.1	X-linked interleukin-1 receptor accessory protein-like 2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	参考文献	由来
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	21926414	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	21926414	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21926414	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21926414	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL1RAPL2 Protein Structure

Ig_2

Ig_3

TIR

0
200
400
600
686 a.a.

Protein Preferred Names	Protein Names
X-linked interleukin-1 receptor accessory protein-like 2	IL-1 receptor accessory protein-like 2

Recombinant IL1RAPL2 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P73151	IL-1R9/IL1RAPL2 Protein, Human (HEK293, Fc)	Q9NP60 (T17-K354)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73895	IL-1R9/IL1RAPL2 Protein, Human (HEK293, His)	Q9NP60 (T17-E356)	≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases	Alias
Cinca Syndrome	CINCA Nomid Cryopyrin-Associated Periodic Syndrome 3 Chronic Neurologic Cutaneous And Articular Syndrome Multisystem Inflammatory Disease, Neonatal-Onset Caps3 Chronic Infantile Neurological Cutaneous Articular Syndrome Infantile-Onset Multisystem Inflammatory Disease Iomid Syndrome Neonatal-Onset Multisystem Inflammatory Disease Nomid Syndrome Prieur-Griscelli Syndrome Neonatal Onset Multisystem Inflammatory Disease Chronic Infantile Neurological, Cutaneous And Articular Syndrome Iomid Infantile Onset Multisystem Inflammatory Disease Prieur Griscelli Syndrome Chronic Infantile Neurological Cutaneous And Articular Syndrome Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome Chronic Infantile Neurologic Cutaneous And Articular Syndrome Chronic Infantile Neurological, Cutaneous, And Articular Syndrome Cryopyrin-Associated Periodic Syndromes
Muckle-Wells Syndrome	MWS Urticaria-Deafness-Amyloidosis Syndrome Uda Syndrome Neutrophilic Urticaria Urticaria, Deafness And Amyloidosis Cryopyrin-Associated Periodic Syndrome 2 Caps2 Muckle Wells Syndrome Urticaria-Deafness-Amyloidosis Cryopyrin-Associated Periodic Syndromes
Adult-Onset Still'S Disease	Adult-Onset Still Disease Adult Onset Still'S Disease Adult Still'S Disease Still'S Disease Adult Onset Aosd Wissler-Fanconi Syndrome Stills Disease Adult-Onset Still'S Disease, Adult-Onset Wissler'S Syndrome
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Schnitzler Syndrome	Chronic Urticaria With Gammopathy Chronic Urticaria With Macroglobulinemia Chronic Urticaria With Gammapathy
Clostridium Difficile Colitis	Pseudomembranous Colitis Colitis Pseudomembranous Enterocolitis, Pseudomembranous Pseudomembranous Enterocolitis Clostridium Difficile Infection
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Blau Syndrome	Arthrocutaneouveal Granulomatosis Jabs Syndrome BLAUS Sarcoidosis, Early-Onset Acug Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial Eos Granulomatosis, Familial Juvenile Systemic Granulomatosis, Familial, Blau Type Familial Juvenile Systemic Granulomatosis Early Onset Sarcoidosis Synovitis Granulomatous With Uveitis And Cranial Neuropathies Early-Onset Sarcoidosis Familial Granulomatosis, Blau Type Pediatric Granulomatous Arthritis Familial Granulomatosis Blau Type Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies
Dengue Shock Syndrome	Dss
Cysticercosis	Neurocysticercosis Submacular Cysticercosis Intestinal Taenia Solium Infection Pork Tapeworm Infection Tapeworm Infection: Intestinal Taenia Solum Tapeworm Infection: Pork Tenia Solium Infectious Disease Taeniasis Tenia Solium Infection Cysticerciasis Infection Due To Larval Form Of Taenia Solium
Dysentery	Infectious Diarrhea
Protein-Energy Malnutrition	PEM Protein Energy Malnutrition
Scleritis
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Proteasome-Associated Autoinflammatory Syndrome 1	Jmp Syndrome Nakajo-Nishimura Syndrome Nkjo Autoinflammation, Lipodystrophy, And Dermatosis Syndrome Proteasome-Associated Autoinflammatory Syndrome 1 And Digenic Forms Nakajo Syndrome PRAAS1 Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature Syndrome Candle Joint Contractures, Muscular Atrophy, Microcytic Anemia, And Panniculitis-Induced Lipodystrophy Aldd Inflammation Joint Contractures - Muscle Atrophy - Microcytic Anemia - Panniculitis-Induced Lipodystrophy Nakajo Nishimura Syndrome Amyotrophy Fat Tissue Anomaly Japanese Autoinflammatory Syndrome With Lipodystrophy Jasl Joint Contractures Muscular Atrophy Microcytic Anemia And Panniculitis-Induced Lipodystrophy Nns Nodular Erythema With Digital Changes Secondary Hypertrophic Osteoperiostosis With Pernio
Indolent Plasma Cell Myeloma	Indolent Myeloma Indolent Multiple Myeloma
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Glycerol Kinase Deficiency	Hyperglycerolemia GKD Gk Deficiency Gk1 Deficiency Deficiency Of Glycerol Kinase Isolated Glycerol Kinase Deficiency Glycerol Kinase Deficiency, Adult Form Glycerol Kinase Deficiency, Juvenile Form Deficiency, Glycerol Kinase
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Psoriasis
Spondylarthropathy	Spondylarthropathies
Temporomandibular Joint Anomaly	Temporomandibular Joint Dysfunction Temporomandibular Joint Disorder Temporomandibular Joint Disease Temporomandibular Jaw Disorder Tmj - [Temporomandibular Joint] Disorder Temporomandibular Developmental Disorder Of Jaw Temporomandibular Dysfunction Temporomandibular Joint Syndrome Temporomandibular Joint-Pain-Dysfunction Syndrome Mandibular Dysfunction Nos Tmj - [Temporomandibular Joint Disorder] Syndrome Tmjpds - [Temporomandibular Joint Pain Dysfunction Syndrome] Tmj - [Temporomandibular Joint] Dysfunction
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS06724	IL1RAPL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20228	Il1rapl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26735	Il1rapl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	IL1RAPL2	MGD	MGI:1913106
Macaca mulatta	IL1RAPL2	VGNC	VGNC:73720
Rattus norvegicus	IL1RAPL2	RGD	RGD:1561761
Others	IL1RAPL2	NCBI