LasR-IN-2
LasR-IN-2 is a LasR inhibitor that forms H-bonding with TRY-56 residue. LasR-IN-2 can be used in the research of bacterial infection, neutropenia, severe burns and chronic lung disease in cystic fibrosis (CF).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3033530-61-6
- 分子式: C21H16ClN3O2
- 分子量:377.82
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
LasR[1]
LasR-IN-2 (Compound 8a, 4.68-150 μg/mL, 24 h) inhibits P. aeruginosa growth[1].
LasR-IN-2 (18.5 μM, 24 h) inhibits biofilm formation, pyocyanin production, and rhamnolipids production[1].
LasR-IN-2 (24 h) inhibits human dermal fibroblasts (HDFa) growth with an IC50 value of 102 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:P. aeruginosa (ATCC27853)
-
Concentration:4.68-150 μg/mL
-
Incubation Time:24 h
-
Result:Inhibited bacterial growth with a MIC value of 74.40 μM.
化学情報
-
CAS 番号 3033530-61-6
-
分子量 377.82
-
分子式 C21H16ClN3O2
-
SMILES
O=C(NC1=CC=CC=C1)COC2=CC=C(C3=NC4=CC(Cl)=CC=C4N3)C=C2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Rehab H Abd El-Aleam, et al. Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation. Eur J Med Chem. 2022 Aug 5;241:114629. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LasR-IN-2 関連分類
HY-151164 関連分類
Powered by Bioz